Browsing by Author "Ölgen, Süreyya"
Now showing items 1-9 of 9
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Design strategies, structures and molecular interactions of small molecule src inhibitors
Ölgen, Süreyya (Bentham Science Publ Ltd, 2016)In recent years, several small molecules approved by FDA for clinical studies are promising anti-cancer agent. Among the kinases, Abelson Leukaemia (Abl), sarcoma (Src), epidermal growth factor receptor (EGFR) and vascular ... -
Drug repurposing in the development of anticancer agents
Ölgen, Süreyya; Kotra, Lakshmi P. (Bentham Science Publ Ltd, 2019)Background: Research into repositioning known drugs to treat cancer other than the originally intended disease continues to grow and develop, encouraged in part, by several recent success stories. Many of the studies in ... -
The effects of 1,3,5-trisubstituted indole derivatives on cell growth, apoptosis and MMP-2/9 mRNA expression of MCF-7 human breast cancer cells
Bakar, Filiz; Kılıç-Kurt, Zühal; Cağlayan, Mehmet Gökhan; Ölgen, Süreyya (Bentham Science Publ Ltd, 2017)Background: Matrix metalloproteinases are known as extracellular matrix degrading enzymes and have important role on tumor progression. Objective: This study reports the effects of 1,3,5-trisubstituted indole derivatives ... -
In vitro antibacterial and antifungal activity and computational evaluation of novel indole derivatives containing 4-substituted piperazine moieties
Altuntaş, Tunca Gül; Yılmaz, Nilüfer; Ece, Abdulilah; Altanlar, Nurten; Ölgen, Süreyya (Bentham Science Publ Ltd, 2018)Background: Lack of specificity and occurence of resistance to current antibacterial and antifungal agents are major shortcomings for the treatment of microbial diseases. Finding novel antimicrobial agents is therefore ... -
Overview on anticancer drug design and development
Ölgen, Süreyya (Bentham Science Publ Ltd, 2018)Background: Many impediments of current anti-cancer therapies have urged scientists to discover new agents. As a result of growing spectrums of new targets and strategies and recent biological and biotechnological progresses, ... -
A prospective overview of drug repurposing in drug discovery and development
Ölgen, Süreyya (Bentham, 2019)The pursuit of approved drugs and unapproved drug candidates repurposing for novel clinical applications is an attractive strategy due to its speed and high efficiency. Most successful repurposing discoveries have been ... -
SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents
Beus, Maja; Rajic, Zrinka; Maysinger, Dusica; Mlinaric, Zvonimir; Antunovic, Maja; Marijanovic, Inga; Fontinha, Diana; Prudencio, Miguel; Held, Jana; Ölgen, Süreyya; Zorc, Branka (ChemPubSoc Europe, 2018)We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial ... -
Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties
Altuntaş, Tunca Gül; Yılmaz, Nilüfer; Çoban, Tülay; Ölgen, Süreyya (Bentham Science Publ Ltd, 2017)Background: Oxidative stress caused by reactive oxygen species (ROS) plays a significant role in many human disorder such as cancer, rheumatoid arthritis, atherosclerosis, stroke, neurodegeneration, and diabetes as well ... -
Tirozin kinaz inhibitörü bileşiklerin tasarımı ve antikanser etki mekanizmaları
Ölgen, Süreyya; Şentürk, Ahmet Mesut (Society of Pharmaceutical Sciences of Ankara (FABAD), 2021)Cancer is a complex disease that is caused by uncontrolled division and proliferation of cells and under the influence of genetic and conditions. There are more than 100 types of cancers known and standardized therapies ...
