Browsing by Author "Ölgen, Süreyya"
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Antimicrobial evaluation, molecular docking and ADME properties of indole amide derivatives
Doğanay, Derya; Özcan, Şevval Maral; Şentürk, Ahmet Mesut; Ölgen, Süreyya (Bentham, 2022)Abstract Background: Besides the viral infections, bacterial infections can cause serious and life-threatening complications and drug resistance is an important problem to fight bacterial infections. There-fore, it is ... -
Clinical trials on combination of repurposed drugs and anticancer therapies
Ölgen, Süreyya (2020)Abstract This chapter provides the clinical applications of existing several therapeutic agents for the treatment of cancer which is called drug repurposing. The main aim of drug repurposing generally is that trying to ... -
Design strategies, structures and molecular interactions of small molecule src inhibitors
Ölgen, Süreyya (Bentham Science Publ Ltd, 2016)In recent years, several small molecules approved by FDA for clinical studies are promising anti-cancer agent. Among the kinases, Abelson Leukaemia (Abl), sarcoma (Src), epidermal growth factor receptor (EGFR) and vascular ... -
Drug repurposing in the development of anticancer agents
Ölgen, Süreyya; Kotra, Lakshmi P. (Bentham Science Publ Ltd, 2019)Background: Research into repositioning known drugs to treat cancer other than the originally intended disease continues to grow and develop, encouraged in part, by several recent success stories. Many of the studies in ... -
The effects of 1,3,5-trisubstituted indole derivatives on cell growth, apoptosis and MMP-2/9 mRNA expression of MCF-7 human breast cancer cells
Bakar, Filiz; Kılıç Kurt, Zühal; Cağlayan, Mehmet Gökhan; Ölgen, Süreyya (Bentham Science Publ Ltd, 2017)Background: Matrix metalloproteinases are known as extracellular matrix degrading enzymes and have important role on tumor progression. Objective: This study reports the effects of 1,3,5-trisubstituted indole derivatives ... -
In vitro antibacterial and antifungal activity and computational evaluation of novel indole derivatives containing 4-substituted piperazine moieties
Altuntaş, Tunca Gül; Yılmaz, Nilüfer; Ece, Abdulilah; Altanlar, Nurten; Ölgen, Süreyya (Bentham Science Publ Ltd, 2018)Background: Lack of specificity and occurence of resistance to current antibacterial and antifungal agents are major shortcomings for the treatment of microbial diseases. Finding novel antimicrobial agents is therefore ... -
Investigating the activity of indole-2-on derivative src kinase inhibitors against chronic myeloid leukemia cells
Çört Dönmez, Aysegül; Ölgen, Süreyya; Güner, Ersin; Akgün Çağlıyan, Gülsüm; Hanikoğlu, Ferhat; Tunç Ata, Melek; Kılıç Toprak, Emine (Bentham Science Publishers, 2023)Background: Src family tyrosine kinases play a potential role in Bcr-Abl-induced leukemogenesis. Src kinase inhibitors are reported as selective inhibitors of chronic myeloid leukemia. Objective: Since Src kinase inhibitors ... -
Overview on anticancer drug design and development
Ölgen, Süreyya (Bentham Science Publ Ltd, 2018)Background: Many impediments of current anti-cancer therapies have urged scientists to discover new agents. As a result of growing spectrums of new targets and strategies and recent biological and biotechnological progresses, ... -
A prospective overview of drug repurposing in drug discovery and development
Ölgen, Süreyya (Bentham, 2019)The pursuit of approved drugs and unapproved drug candidates repurposing for novel clinical applications is an attractive strategy due to its speed and high efficiency. Most successful repurposing discoveries have been ... -
SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents
Beus, Maja; Rajic, Zrinka; Maysinger, Dusica; Mlinaric, Zvonimir; Antunovic, Maja; Marijanovic, Inga; Fontinha, Diana; Prudencio, Miguel; Held, Jana; Ölgen, Süreyya; Zorc, Branka (ChemPubSoc Europe, 2018)We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial ... -
Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties
Altuntaş, Tunca Gül; Yılmaz, Nilüfer; Çoban, Tülay; Ölgen, Süreyya (Bentham Science Publ Ltd, 2017)Background: Oxidative stress caused by reactive oxygen species (ROS) plays a significant role in many human disorder such as cancer, rheumatoid arthritis, atherosclerosis, stroke, neurodegeneration, and diabetes as well ... -
Synthesis of novel urea and sulfonamide derivatives of isatin schiff bases as potential anti - cancer agents
Demirel, Ural Ufuk; Ölgen, Süreyya; Karaman, Ecem Fatma; Tanol, Mehmet; Özden, Sibel; Göker, Hakan (Bentham Science Publishers, 2022)Background: Among the many types of chemical scaffolds, isatin derivatives, including their Schiff bases, have been extensively studied to find novel therapeutic agents against cancer. Amide or urea groups containing ... -
Tirozin kinaz inhibitörü bileşiklerin tasarımı ve antikanser etki mekanizmaları
Ölgen, Süreyya; Şentürk, Ahmet Mesut (Society of Pharmaceutical Sciences of Ankara (FABAD), 2021)Cancer is a complex disease that is caused by uncontrolled division and proliferation of cells and under the influence of genetic and conditions. There are more than 100 types of cancers known and standardized therapies ...
