Browsing by Author "Kılınç, Erkan"
Now showing items 1-9 of 9
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The comparison of effects of applications of compound 48/80 and mast cell mediator suspension on inflammation in rats: a methodological study for acute inflammatory pain
Kılınç, Erkan; Dağıstan, Yaşar; Çetinkaya, Ayhan; Töre, Fatma (Marmara Üniversitesi, 2019)Objective: Inflammation underlies the pathological basis of most diseases. Substance-P is a key mediator that participates in various inflammatory processes and painful conditions. Mast cells (MCs) have a key role in ... -
Mast cell degranulation mediates oompound 48/80-induced meningeal vasodilatation underlying migraine pain
Kılınç, Erkan; Dağıstan, Yaşar; Töre, Fatma (Marmara Üniversitesi, 2018)Objective: The cranial dura mater contains plenty of mast cells and is principally supplied by the middle meningeal artery which has a key role in the generation of headaches. Neurogenic inflammation caused by perivascular ... -
Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats
Kılınç, Erkan; Dağıstan, Yaşar; Kükner, Aysel; Yılmaz, Bayram; Ağuş, Sami; Söyler, Gizem; Töre, Fatma (WILEY, 2018)The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this ... -
Salmon calcitonin ameliorates nitroglycerin-induced migraine pain through inhibition of calcitonin-gene related peptide release from trigeminal neurons and c-fos expression in trigeminal nucleus caudalis in rats
Kılınç, Erkan; Dağıstan, Yaşar; Kükner, Aysel; Söyler, Gizem; Töre, Fatma (Wiley, 2017) -
Serotonergic mechanisms of trigeminal meningeal nociception: Implications for migraine pain
Kılınç, Erkan; Guerrero-Toro, Cindy; Zakharov, Andrey; Vitale, Carmela; Gubert-Olive, Max; Koroleva, Ksenia; Timonina, Arina; Luz, Liliana L.; Shelukhina, Irina; Giniatullina, Raisa; Töre, Fatma; Safronov, Boris V.; Giniatullin, Rashid (Pergamon-Elsevier Science Ltd., 2017)Serotonergic mechanisms play a central role in migraine pathology. However, the region-specific effects of serotonin (5-HT) mediated via multiple types of receptors in the nociceptive system are poorly understood. Using ... -
Shared fate of meningeal mast cells and sensory neurons in migraine
Irmak, Duygu Koyuncu; Kılınç, Erkan; Töre, Fatma (Frontiers Media SA, 2019)Migraine is a primary headache disorder which has complex neurogenic pathophysiological mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell couplings in the migraine target tissue are ... -
Thymoquinone inhibits neurogenic inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate-induced migraine model in rats
Kılınç, Erkan; Töre, Fatma; Dağıstan, Yaşar; Buğdaycı, Güler (Springer Nature Switzerland, 2019)Two main contributors of sterile neurogenic inflammation underlying migraine pain, calcitonin gene–related peptide (CGRP), and meningeal mast cells (MMCs) play a key role in the activation of the inflammatory cascade ...
