Browsing by Author "Karaman, Berin"
Now showing items 1-3 of 3
-
Computational drug repurposing: Current trends
Karaman, Berin; Sippl, Wolfgang (Bentham Science Publishers, 2019)Biomedical discovery has been reshaped upon the exploding digitization of data which can be retrieved from a number of sources, ranging from clinical pharmacology to cheminformatics-driven databases. Now, supercomputing ... -
Identification of bichalcones as natural product sirtuin inhibitors by virtual screening and in vitro testing
Karaman, Berin; Alhalabi, Zayan; Swyter, Soeren; Mihigo, Shetonde; Andrae-Marobela, Kerstin; Jung, Manfred; Sippl, Wolfgang; Ntie-Kang, Fidele (Amer Chemical Soc, 2018)Sirtuins are nicotinamide adenine dinucleotide (NAD+ )-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and ... -
Increased potency and selectivity for group III metabotropic glutamate receptor agonists binding at dual sites
Selvam, Chelliah; Lemasson, Isabelle A.; Brabet, Isabelle; Oueslati, Nadia; Karaman, Berin; Cabaye, Alexandre; Tora, Amelie S.; Commare, Bruno; Courtiol, Tiphanie; Cesarini, Sara; McCort-Tranchepain, Isabelle; Rigault, Delphine; Mony, Laetitia; Bessiron, Thomas; McLean, Heather; Leroux, Frederic R.; Colobert, Francoise; Daniel, Herve; Goupil-Lamy, Anne; Bertrand, Hugues-Olivier; Goudet, Cyril; Pin, Jean-Philippe; Acher, Francine C. (Amer Chemical Soc, 2018)A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an L-AP4-derived fragment that mimics glutamate and a chain that binds into a neighboring ...