Browsing by Author "Sezerman, Osman Uğur"

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Assessment of global and gene-specific DNA methylation in rat liver and kidney in response to non-genotoxic carcinogen exposure

Özden, Sibel; Kara, Neslihan Turgut; Sezerman, Osman Uğur; Durası, İlknur Melis; Chen, Tao; Demirel, Göksun; Alpertunga, Buket; Chipman, J. Kevin; Mally, Angela (Academic Press Inc., 2015)

Altered expression of tumor suppressor genes and oncogenes, which is regulated in part at the level of DNA methylation, is an important event involved in non-genotoxic carcinogenesis. This may serve as a marker for early ...
Probing the structural dynamics of the catalytic domain of human soluble guanylate cyclase

Khalid, Rana Rehan; Maryam, Arooma; Sezerman, Osman Uğur; Mylonas, Efstratios; Siddiqi, Abdul Rauf; Kokkinidis, Michael (Springer Nature, 11.07.2020)

In the nitric oxide (NO) signaling pathway, human soluble guanylate cyclase (hsGC) synthesizes cyclic guanosine monophosphate (cGMP); responsible for the regulation of cGMP-specific protein kinases (PKGs) and phosphodiesterases ...