Circulating miR-21 levels in hypertensive patients with asymptomatic organ damage

Abstract

Abstract As a modifiable risk factor for cardiovascular disease, presence of hypertension (HT) necessitates the awareness of asymptomatic organ damage (AOD). The aim of this study was to measure plasma micro RNA-21 (miR-21) and the parameters that reflect AOD such as carotid intima-media thickness (CIMT), microalbuminuria (MAU) in hypertensive patients compared with healthy controls. In addition, the aim of this study was to evaluate plasma miR-21 levels in HT patients with AOD. This study was designed as a cross-sectional observational study. The study includes 2 groups: 32 patients with HT and 32 healthy controls. First, we compared these 2 groups. Then, to underline the relationship between plasma miR-21 and HT, hypertensive patients were divided into 2 groups: with AOD and without AOD. Sixteen patients with HT had AOD. MiR-21 levels significantly correlated with clinical systolic and diastolic blood pressure, MAU, Creactive protein, and CIMT. CIMT, miR-21, and MAU levels were significantly higher in patients with AOD. Our study showed increased miR-21 levels in HT patients with AOD. Abbreviations: AOD = asymptomatic organ damage, AUC = area under curve, BSA = body surface area, CIMT = carotid intima– media thickness, CrCI = creatinine clearance, CRP = C-reactive protein, D = disease, DBP = diastolic blood pressure, eGFR = estimated glomerular filtration rate, F = female, HDL = high-density lipoprotein, HT = hypertension, IVSTd = interventricular septal diastolic thickness, LDL = low-density lipoprotein, LVDd = left ventricular end-diastolic diameter, LVH = left ventricular hypertrophy, LVM = left ventricular mass, LVPWTd = left ventricular posterior wall diastolic thickness, M = male, MAU = microalbuminuria, miR-21 = micro RNA-21, mRNA = messenger RNA, RNA = ribonucleic acid, ROC = receiver operating characteristic, SBP = systolic blood pressure, T = total.