Tıbbi Farmakoloji Ana Bilim Dalı
Recent Submissions
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Influence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in rats
(Frontiers Media S.A., 06.06.2022)The underlying mechanism of dependence and rewarding effects of morphine is imperative to understand. The primary aim of this study was to investigate whether ropinirole D2/3 agonist affects the rewarding and reinforcing ... -
The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis
(Turkiye Klinikleri, 2022)Background/aim: Hashimoto thyroiditis (HT) is one of the most prevalent autoimmune diseases. The intestine microbiota is strongly associated with autoimmune diseases. Zonulin, a modulator of tight junctions that controls ... -
Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension
(Elsevier, 2022)Background: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, ... -
Pleiotropic effects of pitavastatin: A pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis
(Verduci Editore s.r.l, 2022)OBJECTIVE: Cardiovascular diseases are responsible for the majority of deaths on a global scale. Atherosclerosis is the main risk factor for cardiovascular disorders and represents a complex phenomenon associated with ... -
Treatment methods for vulvovaginal candidiasis in pregnancy
(Elsevier, 2021)Introduction: Vulvovaginal candidiasis (VVC) is one of the three most common vaginal infections of women. Our goal is to check which treatment method (vaginal or vaginal combined with oral) is more effective for each ... -
Does tacrolimus use have a sexual dysfunctional effect in women after renal transplant?
(Elsevier, 2022)Background. Tacrolimus, one of the immunosuppressive agents, is used to prevent tissue rejection in renal transplant recipients, but the relationship between the plasma concentrations of tacrolimus and female sexual ... -
Vitamin D mitigates atherosclerosis risk in TNF-α-induced endothelial cells
(University of Benin, 2022)Abstract Purpose: To determine the effect of vitamin D on endothelial function in a cell line model of inflammation. Methods: Human saphenous vein cells were treated with 1,25-dihydroxyvitamin D3 (1,25-OHD) and/or TNF-α, ... -
TNF-α ile oluşturulan in vitro insan safen ven ateroskleroz modelinde atorvastatin ve pitavastatinin matriks metalloproteinaz 2 üzerine etkilerinin karşılaştırılması
(İzmir Hastanelerine Yardım ve Bilimsel Araştırmaları Teşvik Derneği, 2021)Giriş: Ateroskleroz, arteryal duvarda kolesterol içeren düşük dansiteli lipoprotein parçacıklarının birikmesi ile tetiklenen farklı tip hücreler ve ekstraselüler matriks birikiminin kalınlaşmaya sebep olduğu kronik ... -
Angioedema after favipiravir treatment: Two cases
(Springer Nature, 17.01.2022)Drug-induced angioedema often affects elderly patients with chronic drug use. Proper diagnosis and prompt with effective treatment reduce mortality. With the increasing use of favipiravir, many side effects, especially ... -
Investigation of interleukin-17 gene-152g/A polymorphism and IL-17 serum levels in patients with cardiac syndrome X
(Galenos Yayıncılık, 2019)Objective: Cardiac syndrome X (CSX) can be defined as experiencing chest pain with angina by patients with normal coronary arteries. Endothelial and microvascular dysfunction is responsible for the pathophysiology of the ... -
The anti - inflammatory effects of anacardic acid on a tnf - α - induced human saphenous vein endothelial cell culture model
(Bentham Science, 22)Abstract: Background and Objective: Coronary bypass operations are commonly performed for the treatment of ischemic heart diseases. Coronary artery bypass surgery with autologous human saphenous vein maintains its importance ... -
Receptor for advanced glycation end products gene polymorphisms in cardiac syndrome X
(Spandidos Publications, 2019)Abstract: Endothelial and microvascular dysfunction serve important roles in the formation and pathogenesis of cardiac syndrome X (CSX). Expression of receptor for advanced glycation end products (RAGE) is suggested to be ... -
The effects of pitavastatin on nuclear factor-kappa b and icam-1 in human saphenous vein graft endothelial culture
(Hindawi, 2019)Objective. To study pitavastatin’s effects on nuclear factor-kappa B (NF-κB ) and adhesion molecules in human saphenous vein graft endothelial culture indicating its pleotropic properties. Materials and Method. Low-dose ...
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