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dc.contributor.authorŞahin, Aylin Yetim
dc.contributor.authorBaş, Firdevs
dc.contributor.authorYetim, Çağçıl
dc.contributor.authorUçar, Ahmet
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorBundak, Rüveyde
dc.contributor.authorDarendeliler, Feyza
dc.date.accessioned2019-12-24T07:24:49Z
dc.date.available2019-12-24T07:24:49Z
dc.date.issued2019en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://doi.org/10.3906/sag-1808-52
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1088
dc.description.abstractDetermination of insulin resistance and its relationship with hyperandrogenemia, anti-Müllerian hormone, inhibin A, inhibin B, and insulin-like peptide-3 levels in adolescent girls with polycystic ovary syndrome Background/aim: This study aims to investigate the association between polycystic ovary syndrome (PCOS) and obesity and insulin resistance (IR) with respect to anti-Müllerian hormone (AMH), inhibin A (INH-A), inhibin B (INH-B), and insulin-like peptide 3 (INSL3) levels, all factors which may have an impact on IR. Materials and methods: In this cross sectional study, 52 adolescent girls diagnosed with PCOS [groups: nonobese (NO), n = 23; overweight/obese (OW/O), n = 29] were included. Blood samples were obtained to measure AMH, INH-B, INH-A, and INSL3 levels, together with hormonal and biochemical assessments. Oral glucose tolerance test (OGTT) was performed and the indexes of IR [homeostasis model assessment: insulin resistance (HOMA-IR) and Matsuda index] were calculated. Results: Insulin resistance was 56.5% with OGTT and 30.4% with HOMA-IR in nonobese-PCOS girls. There was a correlation between INH-A and HOMA-IR even when controlled for body mass index (BMI). INH-B and FAI also had correlations with HOMA-IR which disappeared when controlled for BMI. In regression analyses, AMH (odds ratio = [0.903, P = 0.015) and FAI (odds ratio = 1.353, P = 0.023) are found to be contributors to IR. Their effect was BMI-independent. In ROC analysis, the cutoff value for FAI was 5.93 (sensitivity 71%) to define IR in PCOS girls. Conclusion: AMH and FAI may contribute to IR (defined by OGTT) in PCOS. FAI might be used as a supporting IR marker (defined by OGTT) in adolescent girls with PCOS.en_US
dc.language.isoengen_US
dc.publisherTubitaken_US
dc.relation.isversionof10.3906/sag-1808-52en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAdolescenten_US
dc.subjectAnti-Müllerian Hormoneen_US
dc.subjectFree Androgen Indexen_US
dc.subjectInsulin Resistanceen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectInhibin Aen_US
dc.subjectInhibin Ben_US
dc.titleDetermination of insulin resistance and its relationship with hyperandrogenemia, anti-Müllerian hormone, inhibin A, inhibin B, and insulin-like peptide-3 levels in adolescent girls with polycystic ovary syndromeen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume49en_US
dc.identifier.issue4en_US
dc.identifier.startpage1117en_US
dc.identifier.endpage1125en_US
dc.relation.publicationcategoryGazete Makalesi - Ulusalen_US


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