• HPV pozitif olan hastaların HPV hakkında bilgileri ve HPV aşılarına yaklaşımı: Tersiyer bir merkezin deneyimi 

  Purut, Yunus Emre; Purut, Şeyma Nur; Giray, Burak; Yazıcı, Zeliha; Kabaca, Canan (Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH, 15.12.2020)

  Amaç: Tersiyer bir merkeze kolposkopik inceleme için refere edilen hastaların Human Papillomavirus (HPV) hakkındaki bilgilerini ve HPV aşısına yaklaşımını değerlendirmeyi amaçladık. Gereçler ve Yöntem: 01.12.2018 ile ...

• Novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety: Anti-inflammatory activity on mammalian macrophages by regulating intracellular PI3K pathway, and molecular docking study 

  Efeoğlu, Çağla; Yetkin, Derya; Nural, Yahya; Ece, Abdulilah; Seferoğlu, Zeynel; Ayaz, Furkan (Elsevier, 15.09.2022)

  In this study, four novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety were synthesized by the reaction of 2,3-diaminonaphthalene-1,4-dione and various isothiocyanate derivatives in 75–88% yield, and their ...

• Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies 

  Yamalı, Cem; Gül, Halise İnci; Tuğrak Sakarya, Mehtap; Nurpelin Sağlık, Begüm; Ece, Abdulilah; Demirel, Göksun; Nenni, Merve; Levent, Serkan; Öner, Ahmet Cihat (Academic Press, 08.2022)

  The research in selective monoamine oxidases (MAO-A and MAO-B) inhibitors has been increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2-(aryl)-4-oxoquinazolin-3(4H)-yl)amino)benze ...

• Resveratrolün kardiyovasküler hastalıklar üzerine etkileri 

  Çıracı, Enver; Kalafat, Tuğçe (Türkiye Diyetisyenler Derneği, 2021)

  Öz:Kardiyovasküler hastalıklar; dünyada mortalitenin önde gelen nedenlerinden biridir. Kardiyovasküler hastalıklarınönlenmesi ve uygulanan tedavilerin etkisinin arttırılmasında, doğal nutrasötikleri kullanan alternatif ...

• TRAIL conjugated silver nanoparticle synthesis, characterization and therapeutic effects on HT-29 colon cancer cells 

  Birtekocak, Fatih; Demirbolat, Gülen Melike; Çevik, Özge (Iranian Journal of Pharmaceutical Research, 2021)

  Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a ...

• Development of a green synthesized silver nanoparticle-based antioxidant capacity method using carob extract 

  Beğiç, Nilay; Bener, Mustafa; Apak, Reşat (Springer, 09.2021)

  The measurement of total antioxidant capacity (TAC) indicating the cooperative action of all antioxidants in a complex sample is an important analytical challenge. A novel green silver nanoparticle-based antioxidant capacity ...

• Green biosynthesis, characterization, and cytotoxic effect of magnetic iron nanoparticles using brassica oleracea var capitata sub var rubra (red cabbage) aqueous peel extract 

  Erdoğan, Ömer; Paşa, Salih; Demirbolat, Gülen Melike; Çevik, Özge (TUBITAK, 2021)

  The green method of nanoparticle synthesis, which is an environment and living-friendly method, is an updated subject that has appeared as an alternative to conventional methods such as physical and chemical synthesis. In ...

• Surface plasmon resonance identifies high-affinity binding of l-DOPA to siderocalin/lipocalin-2 through Iron – siderophore action: Implications for parkinson’s disease treatment 

  Alhassen, Sammy; Senel, Mehmet; Alachkar, Amal (American Chemical Society, 12.2021)

  Abstract: L-3,4-Dihydroxyphenylalanine (L-DOPA), the dopamine precursor, remains the frontline treatment for Parkinson's disease (PD). With the treatment progress, L-DOPA efficacy decreases, necessitating higher and more ...

• The effect of cell-free supernatants of free-living amoeba against some staphylococcus bacteria: First findings from Turkey 

  Özcan, Şevval Maral; Zeybek, Zuhal (Istanbul University Press, 2021)

  Objective: Free-living amoeba (FLA) are protozoa living in soil and in natural and man-made water systems. They attract much attention owing to the illnesses associated with them and to their relationships with bacteria. ...

• Electrospun nanofibers for dual and local delivery of neuroprotective drugs 

  Haidar, Mohammad Karim; Timur, Selin Seda; Demirbolat, Gülen Melike; Nemutlu, Emirhan; Gürsoy, R. Neslihan; Ulubayram, Kezban; Öner, Levent; Eroğlu, Hakan (Korean Fiber Society, 02.2021)

  Drug delivery for neuroprotection/neuroregeneration after traumatic peripheral nerve injuries still remains a challenge. For this purpose, we formulated composite nanofiber formulation for the dual local delivery of alpha ...

• In vitro antimicrobial, antibiofilm and cytotoxic activities of the extracts of arum italicum miller leaves 

  Hacıoğlu, Mayram; Kulaksız, Büşra; Alpınar, Kerim; Hacıosmanoğlu, Ebru; Tan, A. Seher Birteksöz (Societatea de Științe Farmaceutice din România (SSFR), 12.11.2021)

  Abstract: In this study, the antimicrobial, antibiofilm and cytotoxic activities of four different extracts which were prepared from the leaves of Arum italicum Miller, were investigated against various pathogenic ...

• Strategic analysis of Turkish over - the - counter drugs (OTC) and non - pharmaceutical products market 

  Memişoğlu, Merve; Bilen, Ömer (Turkish Pharmacists' Association, Academy of Pharmacy, 06.2021)

  GİRİŞ ve AMAÇ: Global olarak Tezgâh Üstü İlaç pazarı önemli ölçüde büyümektedir. Bu bağlamda çalışmamızda, reçetesiz ilaçların yanı sıra, bitkisel ürünler, gıda takviyeleri ve diğer sağlık ürünleri gibi ilaç dışı ürünler ...

• A novel electrolytes for redox flow batteries: Cerium andchromium couples in aqueous system 

  Koçyiğit, Nilüfer; Gençten, Metin; Şahin, Mutlu; Şahin, Yücel (John Wiley and Sons, 05.2021)

  In this study, Ce/Cr redox flow battery system (RFB), which had redox pair indifferent oxidation states, was performed in aqueous acidic medium for thefirst time in the literature. At Ce/Cr RFB system, optimization of acid ...

• Investigation the effects of synthetic cannabinoid-AKB48 on DNA methylation via the regulation of cannabinoid receptor gene specific methylation in vitro 

  Karaman, Ecem Fatma; Yiğiter, Şemsinur; Özden, Sibel (Marmara Üniversitesi, 2021)

  ABSTRACT: Synthetic cannabinoids have become a significant public health problem in the world because of inexpensive, easy to obtain, difficult to detect by many screening methods, constantly new compounds are produced and ...

• The role of ointment base on stability of dexketoprofen trometamol in ointments 

  Demirbolat, Gülen Melike; Demirel, Abdurrahman (Marmara University, 2021)

  ABSTRACT: The stability of the active pharmaceutical ingredients (API) and the final product is one of the most important factors in the design and development of drug forms. The storage conditions stated on the product ...

• The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells 

  Karaman, Ecem Fatma; Doğan, Esma; Alga, Dilara; Özden, Sibel (İstanbul Üniversitesi, 08.2021)

  Background and Aims: Prochloraz (PCZ) is an imidazole fungicide which is used in agriculture and gardening. PCZ, with endocrine disrupting effect, disrupts reproductive and developmental functions. Previously, the effects ...

• Development of a new drug delivery system from HELA‑derived exosomes and the effect of docetaxel‑loaded exosomes on mitochondrial apoptosis 

  Cenik, Melike; Abas, Burçin İrem; Kocabıyık, Bilge; Demirbolat, Gülen Melike; Çevik, Özge (Springe, 04.09.2021)

  Purpose Exosomes have the potential to create new therapeutics as drug loading carriers. Their important inherent roles are stem from structures (also known natural liposomes) and strong biological stability in many cellular ...

• Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes 

  Hanikoğlu, Ayşegül; Küçüksayan, Ertan; Hanikoğlu, Ferhat; Özben, Tomris; Menounou, Georgia; Sansone, Anna; Chatgilialoglu, Chrys; Di Bella, Giuseppe; Ferreri, Carla (International Academy of Cardiovascular Sciences, 24.03.2020)

  Breast cancer is a worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several treatment options. Extensive literature is available demonstrating ...

• Long chain fatty acids can form aggregates and affect the membrane integrity 

  Demirbolat, Gülen Melike; Coşkun, Göknil Pelin; Erdoğan, Ömer; Çevik, Özge (Elsevier, 08.2021)

  Stearic acid (SA) and oleic acid (OA) which are inherently existing fatty acids (FAs) in the body can alter cell membrane function and interact with each other. However, discrepancies arise as to whether these effects are ...

• Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors 

  Aşkın, Sercan; Tahtacı, Hakan; Türkeş, Cüneyt; Demir, Yeliz; Ece, Abdulilah; Akalın-Çiftçi, Gülşen; Beydemir, Şükrü (Elsevier, 08.2021)

  Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ...

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