• Formation of quantum water in nanoparticulate systems 

  Yerlikaya, Fırat; Camlık, Gamze; Küpeli Akkol, Esra; Değim, Zelihagül; Değim, İsmail Tuncer; Sobarzo-Sanchez, Eduardo (Editions de Sante, 2021)

  The development or designing of new and futuristic drug delivery systems have been mainly focused on nanoparticles and the drug, but the alteration of water properties or configuration of water molecules in these formulations ...

• Glutamine - driven metabolic adaptation to COVID-19 infection 

  Aydın, Hüseyin; Tekin, Yusuf Kenan; Korkmaz, İlhan; Tekin, Gülaçan; Yurtbay, Sefa; Keleş, Sami; Hekim, Nezih (Springer Nature, 2022)

  Abstract Background COVID-19 is known to be transmitted by direct contact, droplets or feces/orally. There are many factors which determines the clinical progression of the disease. Aminoacid disturbance in viral disease ...

• Development and characterization of nano-sized emulsion systems incorporated polyphenolic compound for application through the skin 

  Samancı, Bülent; Yener, Fatma Gülgün; Değim, İsmail Tuncer (Society of Pharmaceutical Sciences of Ankara, 2022)

  In addition to having strong anti-oxidant properties, resveratrol has anti-cancer, anti-angiogenic, cardioprotective, anti-diabetic, antiviral, and neuroprotective activities. Despite its rapid absorption, first-pass effect ...

• Antimicrobial evaluation, molecular docking and ADME properties of indole amide derivatives 

  Doğanay, Derya; Özcan, Şevval M.; Şentürk, Ahmet M.; Ölgen, Süreyya (Bentham, 2022)

  Abstract Background: Besides the viral infections, bacterial infections can cause serious and life-threatening complications and drug resistance is an important problem to fight bacterial infections. There-fore, it is ...

• Ultrasensitive electrochemical detection of carcinoembryonic antigen with a label - free immunosensor using gold nanoparticle - decorated poly (pyrrole-co-3,4-ethylenedioxythiophene) 

  Dokur, Ebrar; Uruç, Selen; Gördük, Özge; Şahin, Yücel (Wiley-Blackwell, 2022)

  Abstract In this study, an electrochemical immunosensor was developed using gold nanoparticles (AuNPs), 3,4-ethylenedioxythiophene (EDOT), and pyrrole (Py) to detect carcinoembryonic antigen (CEA) sensitively. Firstly, the ...

• Synthesis of novel urea and sulfonamide derivatives of isatin schiff bases as potential anti - cancer agents 

  Demirel, Ural Ufuk; Ölgen, Süreyya; Karaman, Ecem Fatma; Tanol, Mehmet; Özden, Sibel; Göker, Hakan (Bentham Science Publishers, 2022)

  Background: Among the many types of chemical scaffolds, isatin derivatives, including their Schiff bases, have been extensively studied to find novel therapeutic agents against cancer. Amide or urea groups containing ...

• Sporcularda kullanımı yasak olan doping etkili maddeler 

  Demirel, Göksun; Doğanay, Derya (Türkiye Klinikleri Yayınevi, 2020)

  ÖZET Dünya üzerinde, ilk çağlardan bu zamana pek çok farklı spor dalı oluşturulduğu, her geçen gün geliştirildiği ve günümüzde de sürdürülmeye devam etmekte olduğu bilinmektedir. Spor dallarında, antrenman performansının ...

• Folic acid conjugated PAMAM-modified mesoporous silica-coated superparamagnetic iron oxide nanoparticles for potential cancer therapy 

  Sağır, Tuğba; Huysal, Merve; Şenel, Mehmet; Işık, Sevim; Burgucu, N.; Tabakoğlu, Haşim Özgür; Zaim, Merve (Elsevier, 11.2022)

  In this study, novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery agents for photodynamic therapy applications. The ...

• 2.Computer-aided drug design symposium and workshop abstract book 

  Ece, Abdulilah; Sheridan, Helen (Biruni Üniversitesi, 2022)

  The focus of the symposium is to bring together academia and industry with an interest in the validation of novel biomolecule targets to treat disease with an unmet clinical need and in applying computational technologies ...

• HPV pozitif olan hastaların HPV hakkında bilgileri ve HPV aşılarına yaklaşımı: Tersiyer bir merkezin deneyimi 

  Purut, Yunus Emre; Purut, Şeyma Nur; Giray, Burak; Yazıcı, Zeliha; Kabaca, Canan (Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH, 15.12.2020)

  Amaç: Tersiyer bir merkeze kolposkopik inceleme için refere edilen hastaların Human Papillomavirus (HPV) hakkındaki bilgilerini ve HPV aşısına yaklaşımını değerlendirmeyi amaçladık. Gereçler ve Yöntem: 01.12.2018 ile ...

• Novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety: Anti-inflammatory activity on mammalian macrophages by regulating intracellular PI3K pathway, and molecular docking study 

  Efeoğlu, Çağla; Yetkin, Derya; Nural, Yahya; Ece, Abdulilah; Seferoğlu, Zeynel; Ayaz, Furkan (Elsevier, 15.09.2022)

  In this study, four novel urea-thiourea hybrids bearing 1,4-naphthoquinone moiety were synthesized by the reaction of 2,3-diaminonaphthalene-1,4-dione and various isothiocyanate derivatives in 75–88% yield, and their ...

• Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies 

  Yamalı, Cem; Gül, Halise İnci; Tuğrak Sakarya, Mehtap; Nurpelin Sağlık, Begüm; Ece, Abdulilah; Demirel, Göksun; Nenni, Merve; Levent, Serkan; Öner, Ahmet Cihat (Academic Press, 08.2022)

  The research in selective monoamine oxidases (MAO-A and MAO-B) inhibitors has been increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2-(aryl)-4-oxoquinazolin-3(4H)-yl)amino)benze ...

• Resveratrolün kardiyovasküler hastalıklar üzerine etkileri 

  Çıracı, Enver; Kalafat, Tuğçe (Türkiye Diyetisyenler Derneği, 2021)

  Öz:Kardiyovasküler hastalıklar; dünyada mortalitenin önde gelen nedenlerinden biridir. Kardiyovasküler hastalıklarınönlenmesi ve uygulanan tedavilerin etkisinin arttırılmasında, doğal nutrasötikleri kullanan alternatif ...

• TRAIL conjugated silver nanoparticle synthesis, characterization and therapeutic effects on HT-29 colon cancer cells 

  Birtekocak, Fatih; Demirbolat, Gülen Melike; Çevik, Özge (Iranian Journal of Pharmaceutical Research, 2021)

  Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a ...

• Development of a green synthesized silver nanoparticle-based antioxidant capacity method using carob extract 

  Beğiç, Nilay; Bener, Mustafa; Apak, Reşat (Springer, 09.2021)

  The measurement of total antioxidant capacity (TAC) indicating the cooperative action of all antioxidants in a complex sample is an important analytical challenge. A novel green silver nanoparticle-based antioxidant capacity ...

• Green biosynthesis, characterization, and cytotoxic effect of magnetic iron nanoparticles using brassica oleracea var capitata sub var rubra (red cabbage) aqueous peel extract 

  Erdoğan, Ömer; Paşa, Salih; Demirbolat, Gülen Melike; Çevik, Özge (TUBITAK, 2021)

  The green method of nanoparticle synthesis, which is an environment and living-friendly method, is an updated subject that has appeared as an alternative to conventional methods such as physical and chemical synthesis. In ...

• Surface plasmon resonance identifies high-affinity binding of l-DOPA to siderocalin/lipocalin-2 through Iron – siderophore action: Implications for parkinson’s disease treatment 

  Alhassen, Sammy; Senel, Mehmet; Alachkar, Amal (American Chemical Society, 12.2021)

  Abstract: L-3,4-Dihydroxyphenylalanine (L-DOPA), the dopamine precursor, remains the frontline treatment for Parkinson's disease (PD). With the treatment progress, L-DOPA efficacy decreases, necessitating higher and more ...

• The effect of cell-free supernatants of free-living amoeba against some staphylococcus bacteria: First findings from Turkey 

  Özcan, Şevval Maral; Zeybek, Zuhal (Istanbul University Press, 2021)

  Objective: Free-living amoeba (FLA) are protozoa living in soil and in natural and man-made water systems. They attract much attention owing to the illnesses associated with them and to their relationships with bacteria. ...

• Electrospun nanofibers for dual and local delivery of neuroprotective drugs 

  Haidar, Mohammad Karim; Timur, Selin Seda; Demirbolat, Gülen Melike; Nemutlu, Emirhan; Gürsoy, R. Neslihan; Ulubayram, Kezban; Öner, Levent; Eroğlu, Hakan (Korean Fiber Society, 02.2021)

  Drug delivery for neuroprotection/neuroregeneration after traumatic peripheral nerve injuries still remains a challenge. For this purpose, we formulated composite nanofiber formulation for the dual local delivery of alpha ...

• In vitro antimicrobial, antibiofilm and cytotoxic activities of the extracts of arum italicum miller leaves 

  Hacıoğlu, Mayram; Kulaksız, Büşra; Alpınar, Kerim; Hacıosmanoğlu, Ebru; Tan, A. Seher Birteksöz (Societatea de Științe Farmaceutice din România (SSFR), 12.11.2021)

  Abstract: In this study, the antimicrobial, antibiofilm and cytotoxic activities of four different extracts which were prepared from the leaves of Arum italicum Miller, were investigated against various pathogenic ...

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