Makale Koleksiyonu
Recent Submissions
-
Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
(Turkish Journal of Medical Sciences, 2021)Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs ... -
Effects of complement regulators and chemokine receptors in type 2 diabetes
(Taylor and Francis, 04.07.2020)CD55 and CD59 are complement regulatory proteins suggested to be related with progression of diabetes and its complications. The stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR4) are chemokine ... -
Assessment of the interaction of aggregatin protein with amyloid-beta (Aβ) at the molecular level via in silico analysis
(Slovenian Chemical Society, 2020)Alzheimer’s disease is a major neurodegenerative illness whose prevalence is increasing worldwide but the molecular mechanism remains unclear. There is some scientific evidence that the molecular complexity of Alzheimer’s ... -
Functional variations of NFKB1 and NFKB1A in inflammatory disorders and their implication for therapeutic approaches
(Sciendo, 2020)Nuclear factor k-light-chain-enhancer of activated B cells (NF-kB) is a sophisticated transcription factor that is particularly important in the inflammatory response, but it regulates more than 400 individual and dependent ... -
The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris
(John Wiley & Sons, 13.05.2020)Background: Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%-100% of patients in a dose-dependent manner. Acneiform folliculitis is considered to be caused ... -
Metformin suppresses the proliferation and invasion through NF-kB and MMPs in MCF-7 cell line
(Türk Biyokimya Derneği, 15.01.2019)Objective: MCF-7 cells, a breast cancer cell line, are used for experiments of estrogen receptor (ER)-positive breast cancer and many sub-clones representing different classes of ER-positive tumors. We aimed to determine ... -
Next-generation sequencing identifies brca1 and/or brca2 mutations in women at high hereditary risk for breast cancer with shorter telomere length
(Mary Ann Liebert, 2020)Telomeres, and telomere length in particular, have broad significance for genome biology and thus are prime research targets for complex diseases such as cancers. In this context, BRCA1 and BRCA2 gene mutations have been ... -
Fas and microRNAs Variations as a Possible Risk for Behçet Disease
(Wolters Kluwer Health, 29-01-2020)Background: Behçet disease (BD) belongs to a disease family that has a transparent borderline between autoinflammatory and autoimmune disorders. Fas and some miRNAs have revealed to display remarkable roles in both autoimmune ... -
Assessment of the rs2645424 C/T single nucleotide polymorphisms in the FDFT1 gene, hepatic expression, and serum concentration of the FDFT patients with nonalcoholic fatty liver disease
(Elsevier Science, 2018)Despite being the most common chronic liver disease, the pathogenesis of nonalcoholic fatty liver disease (NAFLD) still remains unclear. According to the genome-wide association studies (GWAS) alternative alleles of the ...