Farmasötik Toksikoloji Ana Bilim Dalı
Recent Submissions
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Investigation the effects of synthetic cannabinoid-AKB48 on DNA methylation via the regulation of cannabinoid receptor gene specific methylation in vitro
(Marmara Üniversitesi, 2021)ABSTRACT: Synthetic cannabinoids have become a significant public health problem in the world because of inexpensive, easy to obtain, difficult to detect by many screening methods, constantly new compounds are produced and ... -
The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells
(İstanbul Üniversitesi, 08.2021)Background and Aims: Prochloraz (PCZ) is an imidazole fungicide which is used in agriculture and gardening. PCZ, with endocrine disrupting effect, disrupts reproductive and developmental functions. Previously, the effects ... -
Benomyl induced oxidative stress related DNA damage and apoptosis in H9c2 cardiomyoblast cells
(Elsevier, 09.2021)Benomyl, benzimidazole group pesticide, has been prohibited in Europe and USA since 2003 due to its toxic effects and it has been still determined as food and environmental contaminant. In the present study, the toxic ... -
Responses of oxidative stress and inflammatory cytokines after zearalenone exposure in human kidney cells
(Wageningen Academic Publishers, 2020)Zearalenone is a mycotoxin widely found worldwide that is produced by several fungal species. Due to its similarity to estradiol, it has been shown to have toxic effects on the reproductive system. Although various animal ... -
Cellular stress pathways are linked to acetamiprid-induced apoptosis in sh-sy5y neural cells
(MDPI, 09.2021)Simple Summary: Neonicotinoids constitute more than one-quarter of the insecticides on the market. Acetamiprid, a widely used neonicotinoid, has been found to be linked with neurological symptoms and there is an urge to ... -
The subcronic effects of acetamipride on the global DNA methylation levels in Sprague-Dawley rat brain and liver
(İstanbul Üniversitesi, 2019)Acetamiprid, which is a neonicotinoid insecticide, is used to control leafy vegetables, fruiting vegetables, fir seeds, citrus fruits, pome fruits, grapes, cotton and ornamental plants and absorbent insects on flowers. The ... -
The subcronic effects of acetamipride on the global DNA methylation levels in Sprague-Dawley rat brain and liver
(İstanbul Üniversitesi, 12.01.2020)Acetamiprid, which is a neonicotinoid insecticide, is used to control leafy vegetables, fruiting vegetables, fir seeds, citrus fruits, pome fruits, grapes, cotton and ornamental plants and absorbent insects on flowers. The ... -
MDMA abuse in relation to microrna variation in human brain ventral tegmental area and nucleus accumbens
(Shaheed Behesti University of Medical Sciences and Health, 04.2019)3,4-methylenedioxymethamphetamine (MDMA) is one of the most widespread illegal drugs, that have been used particularly by young people in the 15-34 age group. MicroRNAs (miRNAs) are endogenously synthesized, non-coding, ... -
Detection of metabolites of the new synthetic cannabinoid CUMYL-4CN-BINACA in authentic urine samples and human liver microsomes using high-resolution mass spectrometry
(WILEY, 2018)CUMYL-4CN-BINACA(1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide) is a recently introduced indazole-3-carboxamide-type synthetic cannabinoid (SC) that was detected in herbal incense seized by of the ...
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