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dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorYakan, Birkan
dc.contributor.authorSoylu, Meltem
dc.contributor.authorKaymak, Emin
dc.contributor.authorSilici, Sibel
dc.date.accessioned2020-03-17T07:14:13Z
dc.date.available2020-03-17T07:14:13Z
dc.date.issued28.01.2020en_US
dc.identifier.issn1300-0179
dc.identifier.issn1303-6114
dc.identifier.urihttps://doi.org/10.3906/zoo-1911-16
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1195
dc.description.abstractAbstract: Obesity is an important public health problem and a risk factor for many chronic diseases, and its prevalence is increasing rapidly. In recent years there has been interest in the impact of nutrients on obesity and this has been addressed as a research topic. Bee bread is a bee product that has recently attracted attention with its macro- and micronutrients and the enzymes and biocomponents it contains. Although there are many studies on the biological properties and effects of bee bread, its effect on obesity with leptin and ghrelin has not been investigated. In this study, 40 Sprague-Dawley adult female rats were separated into 4 groups after they had become obese by having been fed with commercial high-fat food. While the 1st group was the control, the 2nd group was the obese control and bee bread was given to the 3rd and 4th groups (100 and 200 mg/kg bw/day), and in the 5th group metformin (300 mg/kg/day) was provided. Histopathological and immunohistochemical analysis was performed in hypothalamus tissues, and biochemical analyses were conducted of blood samples and hypothalamus tissues by ELISA methods. The apoptotic cell level was determined by the TUNEL method. The results of the immunohistochemical assessment of the hypothalamus tissues were consistent, and the levels of leptin and ghrelin were inversely correlated in the samples. Biochemical analysis showed that MDA levels increased with obesity whereas differences in SOD, CAT, and XOD levels were not statistically significant. Bee bread improved lipid peroxidation caused by obesity. It was shown that obesity caused apoptotic cell count increase and bee bread decreased it. Bee bread administration (200 mg/kg/day) had positive effects on weight control and other parameters.en_US
dc.language.isoengen_US
dc.publisherScientific and Technical research Council of Turkey - TUBITAK/Turkiye Bilimsel ve Teknik Arastirma Kurumuen_US
dc.relation.isversionofhttps://doi.org/10.3906/zoo-1911-16en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectBee Breaden_US
dc.subjectLeptinen_US
dc.subjectGhrelinen_US
dc.subjectObesityen_US
dc.subjectApoptosisen_US
dc.subjectOxidative Stressen_US
dc.titleThe effects of feeding obese rats with bee bread on leptin and ghrelin expressionen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Zoologyen_US
dc.contributor.departmentSağlık Bilimleri Fakültesien_US
dc.contributor.authorID0000-0002-6980-3384en_US
dc.contributor.authorID0000-0002-5456-4579en_US
dc.contributor.authorID0000-0001-6968-8729en_US
dc.contributor.authorID0000-0002-3818-2693en_US
dc.contributor.authorID0000-0003-2810-2917en_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.endpage125en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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