Predictors of colonic pathologies in active acromegaly: single tertiary center experience
Çiftçi Doğanşen, Sema
Yenidünya Yalın, Gülşah
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Background Regarding the incidence of colorectal malignancy and polyps in patients with acromegaly, studies reported different results in different populations. For this reason, the aim of this study was to determine the frequency of possible colonic pathologies, such as diverticula, polyps, and malignancies in Turkish patients with active acromegaly and factors affecting them. Methods A total of 134 patients with acromegaly and 134 patients with irritable bowel syndrome/dyspeptic symptoms as a control group were included in the study. None of these patients had a previous or family history of colonic neoplasms. Colonoscopies of patients with acromegaly were performed before definitive surgery in a single center by experienced endoscopists. Results The acromegaly and control groups were similar in terms of age and sex. The incidence of all colonic polyps was significantly higher in the acromegaly group (p= 0.012). The frequency of hyperplastic polyps was also increased in the acromegaly group (p= 0.004); however, the frequencies of adenoR. Iliaz, M.D. () Biruni Faculty of Medicine, Department of Gastroenterology, Biruni University, 34295 Istanbul, Turkey firstname.lastname@example.org S. C. Dogansen · S. Tanrikulu · G. Y. Yalin · S. Yarman Istanbul Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey B. Cavus · F. Akyuz Istanbul Faculty of Medicine, Department of Gastroenterology, Istanbul University, Istanbul, Turkey M. Gulluoglu Istanbul Faculty of Medicine, Department of Pathology, Istanbul University, Istanbul, Turkey matous polyps and colonic diverticula were similar in both groups. In the comparison of patients with acromegaly for the presence of polyps, those with polyps were older, had higher levels of insulin-like growth factor (IGF-1), were of male sex, and skin tags were more common (p= 0.016, p= 0.034, p= 0.006 and p= 0.001, respectively). There were no colorectal malignancies in the patients with active acromegaly. Conclusion The frequency of hyperplastic polyps was increased, whereas colonic malignancy was not observed in Turkish patients with active acromegaly.
SourceWiener Klinische Wochenschrift
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