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dc.contributor.authorAydın, Hüseyin
dc.contributor.authorEngin, Aynur
dc.contributor.authorKeleş, Sami
dc.contributor.authorErtemur, Zeynep
dc.contributor.authorHekim, Nezih
dc.date.accessioned2020-08-31T08:48:26Z
dc.date.available2020-08-31T08:48:26Z
dc.date.issued08.04.2020en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.urihttps://doi.org/10.1002/jmv.25872
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1388
dc.description.abstractCrimean‐Congo hemorrhagic fever (CCHF) is a viral disease. There is not enough knowledge about plasma amino acid levels in CCHF. Therefore, we investigated plasma amino acid levels in patients with CCHF and the association between the levels of these amino acids and disease severity. The plasma amino acid levels (including glutamate [Glu], aspartate [Asp], glutamine [Gln], asparagine [Asn] and gamma‐aminobutyric acid [GABA]) in CCHF patients and controls were measured by using liquid chromatography‐mass spectrometry. Plasma levels of Gln were lower while Asp, Glu, and GABA levels were higher in patients. In fatal CCHF patients, we found the plasma level of Asn was increased whereas the plasma level of GABA was decreased. This study is the first in the literature to evaluate the plasma Gln, Glu, Asn, Asp, and GABA levels in CCHF patients. We found that the plasma Gln levels were significantly lower in CCHF patients while Asp, Glu, and GABA levels were elevated. Considering that these amino acids are important for immune cells, the plasma amino acid levels of CCHF patients may contribute to the understanding of the pathophysiology of disease and it can be important for supportive treatment of CCHF.en_US
dc.language.isoengen_US
dc.publisherWiley Periodicalsen_US
dc.relation.isversionofhttps://doi.org/10.1002/jmv.25872en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectBiochemical Analysisen_US
dc.subjectCrimean‐Congo Hemorrhagic Fever Virusen_US
dc.subjectMetabolic Analysisen_US
dc.subjectResearch and Analysis Methodsen_US
dc.subjectVirus Classificationen_US
dc.titleGlutamine depletion in patients with Crimean‐Congo hemorrhagic feveren_US
dc.typearticleen_US
dc.relation.journalJournal of Medical Virologyen_US
dc.contributor.departmentMühendislik ve Doğa Bilimleri Fakültesien_US
dc.contributor.authorID0000-0002-8533-8793en_US
dc.contributor.authorID0000-0003-0177-3649en_US
dc.contributor.authorID0000-0002-7365-9581en_US
dc.contributor.authorID0000-0002-3194-830Xen_US
dc.contributor.authorID0000-0003-2613-8676en_US
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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