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dc.contributor.authorÖnal, Burak
dc.contributor.authorÖzen, Deniz
dc.contributor.authorDemir, Bülent
dc.contributor.authorGezen Ak, Duygu
dc.contributor.authorDursun, Erdinç
dc.contributor.authorDemir, Caner
dc.contributor.authorAkkan, Ahmet Gökhan
dc.contributor.authorÖzyazgan, Sibel
dc.date.accessioned2020-11-27T07:29:38Z
dc.date.available2020-11-27T07:29:38Z
dc.date.issued22en_US
dc.identifier.issn1389-2010
dc.identifier.urihttps://doi.org/10.2174/1389201020666191105154619
dc.identifier.uri1873-4316
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1469
dc.description.abstractAbstract: Background and Objective: Coronary bypass operations are commonly performed for the treatment of ischemic heart diseases. Coronary artery bypass surgery with autologous human saphenous vein maintains its importance as a commonly used therapy for advanced atherosclerosis. Vascular inflammation-related intimal hyperplasia and atherosclerotic progress have major roles in the pathogenesis of saphenous vein graft disease. Methods: In our study, we investigated the effect of anacardic acid (AA), which is a bioactive phytochemical in the shell of Anacardium occidentale, on atherosclerosis considering its inhibitory effect on NF-κB. We observed relative ICAM-1 and NF-κB mRNA levels by qRT-PCR method in a TNF-αinduced inflammation model of saphenous vein endothelial cell culture after 0.1, 0.5, 1 and 5 µM of AA were applied to the cells. In addition, protein levels of ICAM-1 and NF-κB were evaluated by immunofluorescent staining. The results were compared between different concentrations of AA, and also with the control group. Results: It was found that 5 µM, 1 µM and 0.5 µM of AA had toxic effects, while cytotoxicity decreased when 0.1 µM of AA was applied both alone and with TNF-α. When AA was applied with TNF-α, there was a decrease and suppression in NF-κB expression compared with the TNF-α group. TNF-α-induced ICAM-1 expression was significantly reduced more in the AA-applied group than in the TNF-α group. Conclusion: In accordance with our results, it can be said that AA has a protective role in the pathogenesis of atherosclerosis and hence in saphenous vein graft disease.en_US
dc.language.isoengen_US
dc.publisherBentham Scienceen_US
dc.relation.isversionofhttps://doi.org/10.2174/1389201020666191105154619en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCoronary Bypassen_US
dc.subjectAnacardic Aciden_US
dc.subjectSaphenous Veinen_US
dc.subjectAtherosclerosisen_US
dc.subjectInflammationen_US
dc.subjectNF-Κben_US
dc.titleThe anti - inflammatory effects of anacardic acid on a tnf - α - induced human saphenous vein endothelial cell culture modelen_US
dc.typearticleen_US
dc.relation.journal22.10.2020en_US
dc.contributor.departmentTıp Fakültesien_US
dc.identifier.volume21en_US
dc.identifier.issue8en_US
dc.identifier.startpage710en_US
dc.identifier.endpage719en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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