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dc.contributor.authorBaşoğlu, Faika
dc.contributor.authorUlusoy-Güzeldemirci, Nuray
dc.contributor.authorAkalın-Çiftçi, Gülşen
dc.contributor.authorÇetinkaya, Serap
dc.contributor.authorEce, Abdulilah
dc.date.accessioned2022-02-25T06:11:55Z
dc.date.available2022-02-25T06:11:55Z
dc.date.issued08.2021en_US
dc.identifier.issn17470277
dc.identifier.urihttps://doi.org/10.1111/cbdd.13896
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1872
dc.description.abstractThe purpose of this study was to synthesize imidazo[2,1-b]thiazole derivatives, characterize them with spectroscopical techniques and investigate for cytotoxic and apoptotic effects on glioma C6 cancer cell line. The in vitro anticancer activities were also investigated against focal adhesion kinase. Most of the compounds, particularly the derivatives carrying 3-oxo-1-tiya-4-azaspiro[4.5]decane moiety, exhibited higher or comparable activities in comparison with the reference drug, cisplatin. Compounds with methyl, propyl, phenyl moieties at the eighth and second position of the spirothiazolidinone ring showed high FAK inhibitory activities. In addition, molecular docking studies shed light on the binding modes of the synthesized compounds. The critical interactions with amino acid residues located in the active site were revealed. The results obtained from both biological assay data and computational results might provide insight into developing new inhibitors against focal adhesion kinase.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionofhttps://doi.org/10.1111/cbdd.13896en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectFocal Adhesion Kinaseen_US
dc.subjectImidazo[2,1-B]Thiazoleen_US
dc.subjectMolecular Dockingen_US
dc.titleNovel imidazo[2,1-b]thiazole-based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis,in silico and in vitro evaluationen_US
dc.typearticleen_US
dc.relation.journalChemical Biology and Drug Designen_US
dc.contributor.departmentEczacılık Fakültesien_US
dc.contributor.authorID0000-0002-4890-3124en_US
dc.contributor.authorID0000-0002-3087-5145en_US
dc.identifier.volume98en_US
dc.identifier.issue2en_US
dc.identifier.startpage1en_US
dc.identifier.endpage13en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess