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dc.contributor.authorÇelik Özenci, Çiler
dc.contributor.authorSırcan-Küçüksayan, Aslınur
dc.contributor.authorŞahin, Pınar
dc.contributor.authorGüngör-Ordueri, Nazlı Ece
dc.contributor.authorCanpolat, Murat
dc.date.accessioned2022-02-28T12:17:06Z
dc.date.available2022-02-28T12:17:06Z
dc.date.issued06.2021en_US
dc.identifier.issn03034569
dc.identifier.urihttps://doi.org/10.1111/and.14010
dc.identifier.urihttps://hdl.handle.net/20.500.12445/1925
dc.description.abstractThe aim of this study is to investigate the efficiency of elastic light single-scattering spectroscopy system, a noninvasive method, to acquire spectra during testicular biopsy from normal and damaged seminiferous tubules with various degrees of germ cell loss. Adult control rats and doxorubicin-injected rats to achieve seminiferous germ cell loss (for 10 days [10D], 20 days [D20], 30 days [D30], 40 days [D40], and 50 days [D50]) were used. Spectroscopic measurements were acquired utilising a single-fibre optical probe, and histopathology of the biopsied testicular tissue samples were compared. Time-dependent testicular damage comprising various degrees of seminiferous tubule degeneration after doxorubicin-administration was observed. In D30, D40 and D50 groups, where significant germ cell loss was identified, elastic light single-scattering spectroscopy system signals were well correlated with disturbed spermatogenesis where significant differences in spectral signals were obtained. Our findings indicate that the elastic light single-scattering spectroscopy system has the potential to enable instant imaging of spermatogenesis in rats and could also be useful in humans for clinical applications, such as to increase sperm recovery success during micro-TESE for men with nonobstructive azoospermia.en_US
dc.language.isoengen_US
dc.publisherBlackwell Publishingen_US
dc.relation.isversionofhttps://doi.org/10.1111/and.14010en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDoxorubicinen_US
dc.subjectMicro-TESEen_US
dc.subjectNonobstructive Azoospermiaen_US
dc.subjectSpectroscopyen_US
dc.subjectTesticular Damageen_US
dc.titlePrediction of the extent of germ cell loss utilising a noninvasive spectroscopy method in rat testicular damage modelen_US
dc.typearticleen_US
dc.relation.journalAndrologiaen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0003-0370-8680en_US
dc.identifier.volume53en_US
dc.identifier.issue5en_US
dc.identifier.startpage1en_US
dc.identifier.endpage7en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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