Can serum anti-mullerian hormone level and LH / FSH ratio BePredictive of clinical pregnancy through intracytoplasmic spermInjection - embryo transfer?

Abstract

OBJECTIVE: To compare clinical pregnancy rate through ICSI-ET between polycystic ovarian syndromepatients and women with normal ovaries (control group). We also investigated whether serum anti-Mullerian hormone level or LH/FSH ratio may predict clinical pregnancy rate in both groups.STUDY DESIGN:In this retrospective study, endocrine/clinical parameters and cycle characteristics ofwomen with polycystic ovarian syndrome (n=32) and women with normal ovaries (n=115) aged <40years were evaluated. RESULTS:Clinical pregnancy rate in polycystic ovarian syndrome group did not differ from that in thecontrol group (31.3% vs. 32.2%, p>0.05, respectively). The LH/FSH ratio was significantly higher inwomen who conceived compared to women who did not in the polycystic ovarian syndrome group (0.9vs. 0.6, respectively, p=0.4). The cut-off value of 0.6 in the LH/FSH ratio predicted clinical pregnancywith a specificity of 76% and a sensitivity of 65% in the polycystic ovarian syndrome group. Anti-Mullerian hormone was significantly higher in women who conceived compared to women who did notin the control group (4.0 ng/mL vs. 2.1 ng/mL, respectively, p=0.4). CONCLUSION: Polycystic ovarian syndrome patients have a similar clinical pregnancy rate with womenhaving normal ovaries through ICSI-ET. The LH/FSH ratio assessed prior to ovulation induction was sig-nificantly higher in pregnant polycystic ovarian syndrome patients compared to polycystic ovarian syn-drome patients who did not conceive. Anti-Mullerian hormone level was significantly higher in pregnantwomen compared to non-pregnant women with normal ovaries.