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dc.contributor.authorHacıhanefioğlu, Burak
dc.contributor.authorSomunkıran, Aslı
dc.contributor.authorMahmutoğlu, İsmet
dc.contributor.authorSerçelik, Alper
dc.contributor.authorToptani, Semra
dc.contributor.authorKervancioglu, Ertan
dc.date.accessioned30.04.201910:49:13
dc.date.accessioned2019-05-30T20:14:51Z
dc.date.available30.04.201910:49:13
dc.date.available2019-05-30T20:14:51Z
dc.date.issued2002
dc.identifier.issn0015-0282
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(01)03210-1
dc.identifier.urihttps://hdl.handle.net/20.500.12445/215
dc.description.abstractObjective: To investigate the effect of an angiotensin-converting enzyme inhibitor, lisinopril, on serum androgen and sex-hormone-binding globulin (SHBG) levels in hypertensive women with polycystic ovary syndrome (PCOS). Design: Prospective, observational study. Setting: Infertility Clinic of the Sani Konukoglu Hospital, Gaziantep, Turkey. Patient(s): Ten hypertensive women with PCOS. Intervention(s): Lisinopril, 10 mg/day, for 4 weeks. Main Outcome Measure(s): Serum levels of gonadotropins, DHEAS, total T, free T, 17?-hydroxyprogesterone (17-OHP), androstenedione, E2, SHBG, TSH, and PRL were determined. Result(s): Hypertension treatment with lisinopril (10 mg/day for 4 weeks) resulted in a statistically significant decrease in serum free T levels. However, there was no difference in the SHBG levels. Conclusion(s): Use of lisinopril, an angiotensin-converting enzyme inhibitor, results in decreased free T levels independently of SHBG. It may affect the free T levels by affecting the ovarian renin-angiotensin system. Copyright © 2002 American Society for Reproductive Medicine.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/S0015-0282(01)03210-1en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin- Converting Enzyme İnhibitoren_US
dc.subjectOvarian Renin- Angiotensin Systemen_US
dc.subjectPCOSen_US
dc.titleEffect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndromeen_US
dc.typearticleen_US
dc.relation.journalFertility and Sterilityen_US
dc.contributor.departmentBiruni Üniversitesien_US
dc.identifier.volume77en_US
dc.identifier.issue3en_US
dc.identifier.startpage526en_US
dc.identifier.endpage528en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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