• The relationship between positivity for COVID-19 RT-PCR and symptoms, clinical findings, and mortality in Turkey 

  Özcan, Erkan; Yavuzer, Serap; Börkü Uysal, Betül; İslamoğlu, Mehmet Sami; İkitimur, Hande; Ünal, Ömer Faruk; Akpınar, Yunus Emre; Seyhan, Serhat; Koç, Suna; Yavuzer, Hakan; Cengiz, Mahir (Taylor & Francis, 2021)

  Abstract Introduction: This study aimed to assess the correlation between nucleic acid amplification test (real-time reverse transcription-polymerase chain reaction, RT-PCR) positivity of patients presenting with suspected ...

• Evaluation of SARS-CoV-2 with a biophysical perspective 

  Barlas, Sait Berk; Adalier, Nur; Dasdağ, Ömer; Dasdağ, Süleyman (Taylor & Francis, 2021)

  Abstract This paper intends to contribute to the collaborative efforts of the scientific community by providing a literature review of the status of the coronavirus research by adding a multi-disciplinary perspective and ...

• The impact of the COVID-19 pandemic on patients with cardiovascular diseases 

  Yavuzer, Serap; Suzan, Veysel (2021)

  Abstract Cardiovascular diseases are the leading cause of morbidity and mortality in the world, but with the Corona Virus Disease-2019 (COVID-19) pandemic emerging at the end of 2019, this issue has gained different ...

• Efficacy and tolerability of current treatments for hormone-refractory prostate cancer patients with visceral metastases 

  Oruç, Zeynep; Kaplan, M. Ali; Karaağaç, Mustafa; Özyurt, Neslihan; Tatlı, Ali Murat; Kaya, Ali Osman; Menekşe, Serkan; Kut, Engin; Koca, Sinan; Sever, Özlem Nuray; Yasin, Arem; Ebinç, Senar (Future Medicine, 2021)

  Abstract Aim: To assess the efficacy and tolerability of the first-line treatment options for hormone-refractory prostate cancer patients with visceral metastases. Materials & methods: The records of 191 patients diagnosed ...

• Combinatorial therapy of high dose vitamin C and PARP inhibitors in DNA repair deficiency: A series of 8 patients 

  Demiray, Mutlu (SAGE, 2020)

  Abstract Background: Tumor-specific DNA repair defects are ubiquitous in cancerous tissue, which offers a potential for clinical gain to build on these perturbations. Intravenous high-dose vitamin C (IVC) triggers the ...

• Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID-19 pneumonia patients 

  Börkü Uysal, Betül; İkitimur, Hande; Yavuzer, Serap; İkitimur, Barış; Uysal, Harun; İslamoğlu, Mehmet Sami; Özcan, Erkan; Aktepe, Emre; Yavuzer, Hakan; Cengiz, Mahir (Wiley-Blackwell, 2020)

  Abstract To recognize the period of exaggerated cytokine response in patients with coronavirus disease 2019 (COVID‐19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. The data ...

• Future perspectives and challenges with CDK4/6 inhibitors in hormone receptor-positive metastatic breast cancer 

  Bayraktar, Soley; Batoo, Sameer; Al-Hattab, Eyad; Basu, Sandeep; Okuno, Scott; Glück, Stefan (Future Medicine, 2020)

  Abstract There are three US FDA-Approved CDK4/6 inhibitors: palbociclib, ribociclib and abemaciclib for patients with HR-positive, HER2-negative (HR+/HER2-) metastatic breast cancer (MBC). They are all equally effective, ...

• Immunotherapy in breast cancer 

  Bayraktar, Soley; Batoo, Sameer; Okuno, Scott; Glück, Stefan (Wolters Kluwer Health, 2019)

  Abstract: The idea of using the immune system to fight cancer is over 100 years old. A new molecular approach led to a better understanding of the immune system. Checkpoint regulation, understanding the roles of Tregs, ...

• Biomarker modulation study of celecoxib for chemoprevention in women at increased risk for breast cancer: A phase II pilot study 

  Bayraktar, Soley; Baghaki, Sema; Wu, Jimin; Liu, Diane D.; Gutierrez-Barrera, Angelica M.; Bevers, Therese B.; Valero, Vicente; Sneige, Nour; Arun, Banu K. (American Association for Cancer Research, 2020)

  In preclinical studies, celecoxib has been associated with reduced risk of breast cancer. In this study, the aim was to assess the biomodulatory effect of celecoxib on blood and benign breast tissue biomarkers in women at ...

• Predictive factors for molecular response in chronic myeloid leukemia: Reduction ratio and halving time of BCR::ABL1 is transcript levels 

  Ceran, Funda; Akıncı, Sema; Uçar, Mehmet Ali; Korkmaz, Gülten; Gündüz, Mehmet; Çavdarlı, Büşranur; Bakanay, Şule Mine; Falay, Mesude; Dağdaş, Simten; Dilek, İmdat; Özet, Gülsüm (Galenos Yayinevi, 2022)

  Objective: Achieving an early molecular response (EMR) is crucial for improving the prognosis of patients with chronic myeloid leukemia (CML). The halving time (HT) and reduction ratio (RR) of BCR::ABL1 transcript levels ...

• Real-life experience regarding clinical characteristics and treatment outcome in non - cutaneous peripheral t-cell lymphomas: A multicenter study of the Turkish hematology research and education group (THREG) 

  Kayıkçı, Ömür; Mehtap, Özgür; Sarı, İsmail; Demirkan, Fatih; Beyan, Cengiz; Çetin, Güven; Vural, Filiz; Yılmaz, Mehmet; Öztürk, Erman; Akpınar, Seval; Eser, Bülent; Gündüz, Mehmet; Büyükaşık, Yahya; Payzın, Bahriye; Yıldırım, Rahşan; Doğu, Mehmet Hilmi; Özkan, Atilla; Kelkitli, Engin; Tekgündüz, Emre (Galenos Yayinevi, 2022)

  Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased ...

• Comparison of three different creatinine clearance calculation methods in patients with type 2 diabetes mellitus 

  Kundaktepe, Fatih Orkun; Erdem, Mustafa Genco; Helvacı, Şerife Ayşen (Archives of Clinical and Experimental Medicine, 2018)

  Aim: To determine the most accurate and useful method for calculating creatinine clearance by comparing the results of different methods. Methods: Type 2 Diabetic 100 patients who have been followed by Okmeydani Training ...

• Outcomes of thymoma after multimodal therapy and determinants of survival: A 16-year experience of a tertiary cancer center 

  Ak, Naziye; Toker, Alper; Kara, Murat; Özkan, Berker; Ülker, Melike; Kaba, Erkan; Yeğen, Gülçin; Karaman, Şule; Dağoğlu, Nergiz; Kaytan Sağlam, Esra; Oral, Ethem Nezih; Kızır, Ahmet; Bayraktar, Soley; Dişçi, Rian; Ferhatoğlu, Ferhat; Aydın, Esra; Vatansever, Sezai; Eralp, Yeşim; Aydıner, Adnan (Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2021)

  Background: In this study, we aimed to evaluate the factors that contribute to survival outcomes in patients with thymoma treated with multimodal approaches. Methods: A total of 203 patients (105 males, 98 females; median ...

• Evaluation of dynamic hyperinflation with negative expiratory pressure method in patients with chronic obstructive pulmonary disease 

  İkitimur, Hande; Uzan, Gülfidan (Galenos Yayınevi, 2019)

  Objective: Chronic Obstructive Pulmonary disease (COPD) is a disease characterized by progressive airflow limitation, which is not fully reversible. Expiratory flow limitation (EFL) is the most common cause of dynamic ...

• Usefulness of the neutrophil-to-lymphocyte ratio to prediction of complications in type 2 diabetes mellitus 

  Şenyiğit, Abdulhalim (Sivas Cumhuriyet Üniversitesi, 2018)

  Objective: Increasing evidences show that the concept of type 2 diabetes mellitus (T2DM) as an inflammatory disease has emerged. The aim of the present study was to investigate the role of neutrophil-tolymphocyte ratio ...

• Influenza and SARS-CoV-2 coinfection during the COVID-19 pandemic 

  İslamoğlu, Mehmet Sami; Börkü Uysal, Betül (Refik Saydam National Public Health Agency, 2021)

  Objective: Because severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which produces pandemic pneumonia and has a more fatal course than seasonal flu, has no effective treatment, protection against secondary ...

• New orders to an old soldier: Optimizing NK cells for adoptive immunotherapy in hematology 

  Gündüz, Mehmet; Ataca Atilla, Pınar; Atilla, Erden (MDPI, 09.2021)

  Abstract: NK (Natural Killer) cell-mediated adoptive immunotherapy has gained attention in hematology due to the progressing knowledge of NK cell receptor structure, biology and function. Today, challenges related to NK ...

• Relationship between antibody levels and SARS-Cov-2 reinfection 

  İslamoğlu, Mehmet Sami; Cengiz, Mahir; Börkü Uysal, Betül; İkitimur, Hande; Özdemir, Zeynep; Karamehmetoğlu, Ahsen; Akbulut, Ayşe Ezgi; Bakdur, Ayşe Nur; Özdemir, Azize; Kayıkçıoğlu, Habibe; Özdemir, Hatice; Üçeş, Rümeysa; Ersoy, Sema; Yavuzer, Serap (Association of Clinical Scientists, 12.2021)

  Objective: In this period when mutant strains are increasing all over the world, studies on how much humoral immunity will protect against the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) are quite limited. The aim of ...

• Antibody responses to COVID‐19 vaccines in older adults 

  Bağ Soytaş, Rabia; Cengiz, Mahir; İslamoğlu, Mehmet Sami; Börkü Uysal, Betül; Yavuzer, Serap; Yavuzer, Hakan (Wiley, 04.2021)

  AbstractBecause of the senescence of the immune system, antibody response to the COVID‐19 vaccines may differ from older to younger adults. The study aim compares thetiters of SARS‐CoV‐2 IgG antibody of patients≥60 years ...

• Case report: Two cases of persistent hiccups complicating COVID-19 

  İkitimur, Hande; Börkü Uysal, Betül; İkitimur, Barış; Umihanic, Sefika; Smajic, Jasmina; Jahic, Rahima; Olcay, Ayhan (American Society of Tropical Medicine and Hygiene, 05.05.2021)

  Two cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded ...

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