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dc.contributor.authorİliaz, Raim
dc.contributor.authorDoğanşen, Sema Çiftçi
dc.contributor.authorTanrıkulu, Seher
dc.contributor.authorYalın, Gülşah Yenidünya
dc.contributor.authorÇavuş, Bilger
dc.contributor.authorGüllüoğlu, Mine
dc.contributor.authorAkyüz, Filiz
dc.contributor.authorYarman, Sema
dc.description.abstractBackground Regarding the incidence of colorectal malignancy and polyps in patients with acromegaly, studies reported different results in different populations. For this reason, the aim of this study was to determine the frequency of possible colonic pathologies, such as diverticula, polyps, and malignancies in Turkish patients with active acromegaly and factors affecting them. Methods A total of 134 patients with acromegaly and 134 patients with irritable bowel syndrome/dyspeptic symptoms as a control group were included in the study. None of these patients had a previous or family history of colonic neoplasms. Colonoscopies of patients with acromegaly were performed before definitive surgery in a single center by experienced endoscopists. Results The acromegaly and control groups were similar in terms of age and sex. The incidence of all colonic polyps was significantly higher in the acromegaly group (p= 0.012). The frequency of hyperplastic polyps was also increased in the acromegaly group (p= 0.004); however, the frequencies of adenomatous polyps and colonic diverticula were similar in both groups. In the comparison of patients with acromegaly for the presence of polyps, those with polyps were older, had higher levels of insulin-like growth factor (IGF-1), were of male sex, and skin tags were more common (p= 0.016, p= 0.034, p= 0.006 and p= 0.001, respectively). There were no colorectal malignancies in the patients with active acromegaly. Conclusion The frequency of hyperplastic polyps was increased, whereas colonic malignancy was not observed in Turkish patients with active acromegaly.en_US
dc.publisherSpringer Wienen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectColonic Polypen_US
dc.subjectColonic Diverticulaen_US
dc.subjectColorectal Neoplasiaen_US
dc.titlePrediciors of colonic pathologies in active acromegaly: single tertiary center experienceen_US
dc.relation.journalWiener Klinische Wochenschriften_US
dc.contributor.departmentBiruni Üniversitesien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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