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dc.contributor.authorAltuntaş, Tunca Gül
dc.contributor.authorYılmaz, Nilüfer
dc.contributor.authorEce, Abdulilah
dc.contributor.authorAltanlar, Nurten
dc.contributor.authorÖlgen, Süreyya
dc.date.accessioned30.04.201910:49:13
dc.date.accessioned2019-05-30T20:39:04Z
dc.date.available30.04.201910:49:13
dc.date.available2019-05-30T20:39:04Z
dc.date.issued2018
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.urihttps://doi.org/10.2174/1570180815666180109161948
dc.identifier.urihttps://hdl.handle.net/20.500.12445/718
dc.descriptionThis work was partially supported by Faculty of Pharmacy, Ankara University, research Fund.en_US
dc.description.abstractBackground: Lack of specificity and occurence of resistance to current antibacterial and antifungal agents are major shortcomings for the treatment of microbial diseases. Finding novel antimicrobial agents is therefore highly needed to develop more potent drugs. Within this framework, several indole derivatives were designed and reported in the literature. Methods: In vitro antibacterial and antifungal activities of previously synthesized novel indole compounds containing 4-substituted piperazine moieties were tested against Staphylococcus aureus (ATCC 25923), Methicilline resistant Staphylococcus aureus (MRSA, ATCC 43300), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6633) and Candida albicans (ATTC 10231). Sultamicillin T, ampicillin, ciprofloxacin and fluconazole were used as positive controls. Molecular docking was used to study the interaction of active compounds with their receptor. Results: Fifteen compounds were synthesized and their antibacterial activities were similar to that of the reference drugs used as controls. Compounds 4 and 15 were more active (MIC 25 mu g/ml) than ampicillin (MIC 50 mu g/ml) against MRSA, while they showed the same activity as sultamicillin T (MIC 25 mu g/ml). All compounds showed lower activity than ciprofloxacin (MIC 25 mu g/ml) against the tested microorganisms. However, none of the compounds showed remarkable antifungal activity against C. albicans. Conclusion: Compound 6 showed the best interaction with the amino acid residues of the targeted cofactor NAD(+).en_US
dc.description.sponsorshipFaculty of Pharmacy, Ankara Universityen_US
dc.language.isoengen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.isversionof10.2174/1570180815666180109161948en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectPiperazineen_US
dc.subjectİndoleen_US
dc.subjectDockingen_US
dc.subjectCiprofloxacinen_US
dc.titleIn vitro antibacterial and antifungal activity and computational evaluation of novel indole derivatives containing 4-substituted piperazine moietiesen_US
dc.typearticleen_US
dc.relation.journalLetters in Drug Design & Discoveryen_US
dc.contributor.departmentBiruni Üniversitesien_US
dc.contributor.authorID0000-0002-3087-5145en_US
dc.identifier.volume15en_US
dc.identifier.issue10en_US
dc.identifier.startpage1079en_US
dc.identifier.endpage1086en_US
dc.relation.tubitakFaculty of Pharmacy, Ankara Universityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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