Browsing Makale Koleksiyonu by Title
Now showing items 1-20 of 45
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Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)
(Spandidos Publications, 06.05.2020)Genome editing techniques are considered to be one of the most challenging yet efficient tools for assisting therapeutic approaches. Several studies have focused on the development of novel methods to improve the efficiency ... -
The altered promoter methylation of oxytocin receptor gene in autism
(Taylor & Francis Ltd, 2016)Autism spectrum disorder (ASD) is one of the lifelong existing disorders. Abnormal methylation status of gene promoters of oxytonergic system has been implicated as among the etiologic factors of ASDs. We, therefore, ... -
ASC-1 is a cell cycle regulatorassociated with severe and mildforms of myopathy
(Wiley-Blackwell, 02.12.2019)Objective: Recently, the ASC-1 complex has been identified as a mechanistic link between amyotrophic lateral sclerosis and spinal muscular atrophy (SMA), and 3 mutations of the ASC-1 gene TRIP4 have been associated with ... -
Circulating miR-21 and eNOS in subclinical atherosclerosis in patients with hypertension
(Taylor & Francis Inc., 2015)Objectives: The aim of this study is to evaluate the relationship of miR-21, nitric oxide (NOx) and endothelial nitric oxide synthase (eNOS) with subclinical atherosclerosis in carotid arteries by measuring carotid intima ... -
Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries
(Wiley, 01.07.2021)Background: The novel coronavirus disease 2019 (COVID‐19) infection may rely on a potential genetic background for the variations in the inflammatory response. We aimed to investigate the possible correlation between ... -
Cytotoxic effects of N-(4-chlorophenyl)-1H-indole-2-carboxamide on bone cancer cells
(Ankara Onkoloji Eğitim ve Araştırma Hastanesi’, 2020)Giriş ve amaç: Osteosarkom, mezenkimal dokulardan türetilmiş, yüksek maligniteli yaygın bir tümördür. Osteosarkom genellikle ergenlerde görülür ve büyüme hızlıdır, metastaz ve mortalite oranları yüksektir ve prognozu ... -
Designing a gold nanoparticle-based nanocarrier for microRNA transfection into the prostate and breast cancer cells
(Wiley-Blackwell, 2014)BackgroundCancer is one of the most common causes of human deaths worldwide. Nanotechnology has the potential to facilitate the detection, diagnosis, and treatment of cancer cases. Successful delivery of nucleic acids into ... -
Differential expression of hypertension-associated microRNAs in the plasma of patients with white coat hypertension
(Wolters Kluwer Health, 2015)White coat hypertension (WCH) is a high cardiovascular risk condition, and a fundamental understanding of the cause and pathophysiology of the disorder is still lacking. Recent studies demonstrated that microRNAs (miRNAs) ... -
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma
(Wiley-Blackwell, 2016)Objective: Head and neck cancer is the sixth most common cancer in worldwide with an increasing incidence rate in recent years. LOXL4 is expressed in several tissues, and its expression has been shown to display a significant ... -
Elucidating the roles of naturally occurring silent mutations in Polycystic Ovary Syndrome (PCOS)
(Elsevier, 09.2020)Polycystic ovary syndrome (PCOS) is a complex genetic disorder, which often causes infertility in women. Most of the PCOS-related genes are also linked with metabolic diseases, inflammatory responses, or certain types of ... -
Enhancing recombinant chaetomium thermophilium formate dehydrogenase expression with CRISPR technology
(Springer, 08.2021)Genetic manipulation of Escherichia coli influences the regulation of bacterial metabolism, which could be useful for the production of different targeted products. The RpoZ gene encodes for the ω subunit of the RNA ... -
Epibrassinolide prevents tau hyperphosphorylation via GSK3β inhibition in vitro and improves caenorhabditis elegans lifespan and motor deficits in combination with roscovitine
(Springer, 09.2021)Glycogen synthase kinase 3β (GSK3β) is considered an important element of glycogen metabolism; however, it has many other regulatory roles. Changes in the GSK3β signaling mechanism have been associated with various disorders, ... -
Expression of soluble, active, fluorescently tagged hephaestin in COS and CHO cell lines
(Pamukkale University, 2020)Abstract: Hephaestin (Hp) is a trans-membrane protein, which plays a critical role in intestinal iron absorption. Hp was originally identified as the gene responsible for the phenotype of sex-linked anaemia in the sla ... -
From natural selection to smart selection
(International Journal of Basic and Clinical Studies, 2017)The sources are limited in nature; organisms with heritable traits that favor survival and reproduction will tend to leave more offspring than their peers, causing the traits to increase in frequency over generations. Thus ... -
Glioblastoma multiforma tedavisinde kanser kök hücrelerinin temozolomide karşı oluşturdukları direnç
(Sakarya Üniversitesi, 2018)Amaç Glioblastoma multiform (GBM), primer beyin tümörleri arasında en sık görülen agresif bir malign kanser türüdür. Bu hastalığın tedavisinde karşılaşılan en büyük zorluk tümörün kendi doğasındaki karmaşıklık ve ilaç ... -
Glutamine depletion in patients with Crimean‐Congo hemorrhagic fever
(Wiley Periodicals, 08.04.2020)Crimean‐Congo hemorrhagic fever (CCHF) is a viral disease. There is not enough knowledge about plasma amino acid levels in CCHF. Therefore, we investigated plasma amino acid levels in patients with CCHF and the association ... -
Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer
(Wiley-Blackwell, 2015)Prostate cancer (PCa) is one of the leading causes of cancer deaths in men. Since there are limited treatment options available for the advanced tumors, there is an urgent need for novel diagnostic tools for PCa. Prostate ... -
Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study
(Springer, 2016)Of all human oral carcinomas, 41 % are localized to the tongue. Despite considerable improvements in both diagnosis and treatment, tongue squamous cell carcinoma (TSCC) has remained one of the most lethal types of cancer. ... -
In vitro investigations of miR 33a expression in estrogen receptor targeting therapies in breast cancer cells
(MDPI, 01.11.2021)Background: Increased fatty acid synthesis leads to the aggressive phenotype of breast cancer and renders efficiency of therapeutics. Regulatory microRNAs (miRNAs) on lipid biosynthesis pathways as miR-33a have potential ...
