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dc.contributor.authorÖzcan, Muhammed Emin
dc.contributor.authorİnce, Bahri
dc.contributor.authorKaradeli, Hasan Hüseyin
dc.contributor.authorGedikbaşı, Asuman
dc.contributor.authorAsil, Talip
dc.contributor.authorAltınöz, Meriç A.
dc.description.abstractObjective: To define whether minor adult hemoglobin A2 (HbA2, alpha 2 delta 2) exerts any protective activity in multiple sclerosis (MS). Methods: HbA2 levels were measured in 146 MS patients with high performance liquid chromatography and association with MS Severity Scores (MSSS) were determined. HbA2 associations with blood count parameters were also studied using blood counts evaluated on the same day of high performance liquid chromatography sampling. Routine biochemical parameters were also determined to rule out elusively influential factors, such as anemia and thyroid disorders. Results: HbA2 levels negatively correlated with MSSS (Spearman correlation, R: -0.186, P=0.025). Exclusion of confounding factors with a generalized linear model revealed an even stronger negative correlation between HbA2 and MSSS (P < 0.001). HbA2 positively correlated with red blood cells (RBCs) (R=0.350, P < 0.001) and in turn, RBCs negatively correlated with MSSS (R=-0.180, P=0.031). Average HbA2 levels were highest among patients treated with interferon beta 1 alpha. Conclusion: RBC fragility is increased in MS, and recent data suggest that circulating free Hb contributes to neural injury in MS. HbA2 and its oxidative denaturation product hemichrome A2 enhance RBC membrane stability to a greater extent than do major HbA or hemichrome A. Reductions in ischemic cerebrovascular vascular events are reported in beta-thalassemia carriers and HbA2 levels are considerably higher in this population. Episodic declines of cerebral blood flow were shown in bipolar disorder, and we have recently shown a protective role of HbA2 against postpartum episodes in females with bipolar disorder. HbA2's erythroprotective functions may reduce free Hb and long-term neural injury in MS.en_US
dc.publisherDove Medical Press Ltden_US
dc.subjectMultiple Sclerosisen_US
dc.subjectAdult Minor Hemoglobinen_US
dc.subjectHemoglobin A2en_US
dc.titleHigher minor hemoglobin A2 levels in multiple sclerosis patients correlate with lesser disease severityen_US
dc.relation.journalNeuropsychiatric Disease and Treatmenten_US
dc.contributor.departmentBiruni Üniversitesien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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