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Synthesis, characterization, preliminary SAR and molecular docking study of some novel substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives as antifungal agents
(Springer Birkhauser, 2017)
The aim of this study was to synthesize imidazo [2,1-b] [1,3,4] thiadiazole derivatives, characterize them with various spectroscopic methods and investigate their antifungal activities. 2- Imino - 1,3,4 - thiadiazole ...
An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study
BackgroundThis study aims to synthesise and characterise novel compounds containing 2-amino-1,3,4-thiadiazole and their acyl derivatives and to investigate antifungal activities. Similarity search, molecular dynamics and ...
Design, synthesis, SAR and molecular modeling studies of novel imidazo [2,1-b][1,3,4] thiadiazole derivatives as highly potent antimicrobial agents
In this study, a novel series of phenyl substituted imidazo[2,1-b][1,3,4]thiadiazole derivatives were synthesized, characterized and explored for antibacterial activity against Gram-negative Escherichia coli, Gram-positive ...
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo[2,1-b][1,3,4]thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors
Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical chemistry, and they have been investigated as bioactive molecules for medicinal chemistry purposes. Classical carbonic anhydrase (CA) ...