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Anti-aging formulation of rosmarinic acid-loaded ethosomes and liposomes
(Taylor & Francis, 2019)
Abstract The study was aimed to evaluate the effectiveness of rosmarinic acid (RA) loaded ethosomes (ETHs) and liposomes (LPs) when subjected to the transdermal application. RA-loaded ETHs and LPs were prepared, optimised, ...
A prospective overview of drug repurposing in drug discovery and development
(Bentham, 2019)
The pursuit of approved drugs and unapproved drug candidates repurposing for novel clinical applications is an attractive strategy due to its speed and high efficiency. Most successful repurposing discoveries have been ...
Synthesis, biological evaluation and in silico modelling studies of 1,3,5- trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors
(Elsevier B.V., 2019)
Inhibition of carbonic anhydrases (CAs, EC 4.2.1.1) has clinical importance for the treatment of several diseases. They participate in crucial regulatory mechanisms for balancing intracellular and extracellular pH of the ...
Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A
(Royal Pharmaceutical Society, 16.04.2020)
Objectives PH46A (1) demonstrates significant anti-inflammatory activity in phenotypic models but its mechanism and site of action have been elusive. Current study focused on the bioactivity of PH46 (2) and related novel ...
E-pharmacophore based virtual screening for identification of dual specific PDE5A and PDE3A inhibitors as potential leads against cardiovascular diseases
(Informa UK Limited, 17.04.2020)
The need of circumventing life-threatening cardiovascular disorders (CVDs) and pulmonary hypertension (PHT) worldwide prompts researchers to develop effective therapeutic agents. Crucial role of cyclic nucleotide ...
