Browsing by Author "Hakan, Mehmet Tolgahan"
Now showing items 1-4 of 4
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Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells
Küçükhüseyin, Özlem; Çakiris, Aris; Hakan, Mehmet Tolgahan; Horozoğlu, Cem; Tüzün, Erdem; Yaylım, İlhan (Taylor & Francis, 2021)Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell ... -
The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer
Horozoğlu, Cem; Sönmez, Dilara; Küçükhüseyin, Özlem; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Arıkan, Soykan; Yaylım, İlhan (De Gruyter, 2021)Abstract: Objectives: Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many cancer types. However, there are limited studies of these ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
Ay, Ebru Nur; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Horozoğlu, Cem; Arıkan, Soykan; Doğan, Mehmet Baki; Akyüz, Filiz; Özsoy Hepokur, Ceylan; Yaylım, İlhan (Taylor and Francis Group, 2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
Horozoğlu, Cem; Sönmez, Dilara; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Kaleler, İslim; Hepokur, Ceylan; Verim, Ayşegül; Yaylım, İlhan (Elsevier GmbH, 12.2021)Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells. Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ...
