Browsing by Author "Yaylım, İlhan"
Now showing items 1-12 of 12
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Assessment of the rs2645424 C/T single nucleotide polymorphisms in the FDFT1 gene, hepatic expression, and serum concentration of the FDFT patients with nonalcoholic fatty liver disease
Çolak, Yaşar; Coşkunpınar, Ender M.; Şenateş, Ebubekir; Oltulu, Yasemin Müşteri; Yaylım, İlhan; Gömleksiz, Özlem Kurnaz; Tiryakioğlu, Necip Ozan; Hastürk, Burcu; Ekmekçi, Cumhur Gökhan; Aydoğan, Hülya Yılmaz (Elsevier Science, 2018)Despite being the most common chronic liver disease, the pathogenesis of nonalcoholic fatty liver disease (NAFLD) still remains unclear. According to the genome-wide association studies (GWAS) alternative alleles of the ... -
The efects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer
Durak, Şermin; Gheybi, Arezoo; Demirkol, Şeyda; Arıkan, Soykan; Zeybek, Z. Ümit; Akyüz, Filiz; Yaylım, İlhan; Küçükhüseyin, Özlem (Springer Nature, 2019)Due to many biological cell functions of vitamin D including regulation of cell survival, proliferation and differentiation, the metabolism of itself gains importance in the development of several types of cancer. This ... -
Effects of genetic variations of MLCK2, AMPD1, and COL5A1 on muscle endurance
Horozoğlu, Cem; Aslan, Halid Emre; Karaağaç, Ali; Küçükhüseyin, Özlem; Bilgiç, Tuğçe; Himmetoğlu, Şölen; Gheybi, Arezoo; Yaylım, İlhan; Zeybek, Ümit (Redprint Editora, 2022)Introduction: Although potential relationships with genetic variants of MLCK2, AMPD1 and COL5A1 have been detected in molecular studies evaluating sports performance from the genetic perspective, there are limited data in ... -
Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells
Küçükhüseyin, Özlem; Çakiris, Aris; Hakan, Mehmet Tolgahan; Horozoğlu, Cem; Tüzün, Erdem; Yaylım, İlhan (Taylor & Francis, 2021)Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell ... -
The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer
Horozoğlu, Cem; Sönmez, Dilara; Küçükhüseyin, Özlem; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Arıkan, Soykan; Yaylım, İlhan (De Gruyter, 2021)Abstract: Objectives: Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many cancer types. However, there are limited studies of these ... -
Investigation of long non-coding RNAs H19 and LINC00675 in colorectal cancers in terms of histopathological features and correlations with plasma markers
Nacarkahya, Gülper; Borazan, Ersin; Horozoğlu, Cem; Yaylım, İlhan (International Institute of Anticancer Research, 2022)Background/aim: Functional and bioinformatic studies provide strong evidence that long non-coding RNAs (lncRNAs) can alter the molecular mechanisms of cancer through their interactions with DNA, RNAs, and proteins. This ... -
Investigation of miR221 and miR222 as biomarkers in non-small Cell lung cancer
Oltulu, Yasemin Müşteri; Coşkunpınar, Ender; Yıldız, Pınar; Karimova, Ayla; Yaylım, İlhan (International Institute of Anticancer Research, 2023)Abstract Background/Aim: Acute liver injury is the hallmark of organ failure in sepsis. Enteral nutrition (EN) is an important clinical therapeutic measure in septic patients. However, the therapeutic effect of EN alone ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
Ay, Ebru Nur; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Horozoğlu, Cem; Arıkan, Soykan; Doğan, Mehmet Baki; Akyüz, Filiz; Özsoy Hepokur, Ceylan; Yaylım, İlhan (Taylor and Francis Group, 2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
Is there any relationship between LGALS3 gene variations and histopathological criteria in laryngeal squamous cell carcinoma (LSCC)?
Horozoğlu, Cem; Demirkol, Şeyda; Verim, Ayşegül; Sönmez, Dilara; Sürmen, Saime; Küçükhüseyin, Özlem; Zeybek, Ümit; Yaylım, İlhan (De Gruyter, 30.12.2021)Objectives: Genetic variations of LGALS3 (Galectin-3) were found to be associated with treatment resistance, mortality, recurrence, high tumor volume and multiple tumor involvement in solid organ cancers. The modulators ... -
Potential role of immune cell genetic variants associated with tumor microenvironment response in laryngeal squamous cell carcinoma (LSCC) in terms of clinicopathological features
Horozoğlu, Cem; Sönmez, Dilara; Demirkol, Şeyda; Hakan, Mehmet Tolgahan; Kaleler, İslim; Hepokur, Ceylan; Verim, Ayşegül; Yaylım, İlhan (Elsevier GmbH, 12.2021)Immunomodulatory signals regulate the self-tolerance, activation, priming and survival processes of T cells. Programmed cell death protein 1 (PD1), Programmed death-ligand 1 (PD-L1) inhibitory signals and CD27, CD28 ... -
Predicting the predisposition to colorectal cancer based on SNP profiles of immune phenotypes using supervised learning models
Çakmak, Ali; Ayaz, Huzeyfe; Arıkan, Soykan; İbrahimzada, Ali R.; Demirkol, Şeyda; Sönmez, Dilara; Hakan, Mehmet T.; Sürmen, Saime; Horozoğlu, Cem; Doğan, Mehmet B.; Küçükhüseyin, Özlem; Cacına, Canan; Kıran, Bayram; Zeybek, Ümit; Baysan, Mehmet; Yaylım, İlhan (Springer Nature, 2022)AbstractThis study explores the machine learning-based assessment of predisposition to colorectal cancer based on single nucleotide polymorphisms (SNP). Such a computational approach may be used as a risk indicator and an ... -
The role of galectin-3 and its genetic variants in tumor risk and survival of patients with surgically resected early-stage non-small cell lung cancer
Terzioğlu Uşak, Şule; Horozoğlu, Cem; Demirkol, Şeyda; Turna, Akif; Yaylım, İlhan (Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2021)Background: The aim of this study was to investigate the possible relationship between galectin-3 gene variants, serum level, gene expression level, and the risks and survivals of resectable non-small cell lung cancer ...
