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Novel POC1A mutation in primordial dwarfism reveals new insights for centriole biogenesis
(Oxford Univ Press, 2015)
POC1A encodes a WD repeat protein localizing to centrioles and spindle poles and is associated with short stature, onychodysplasia, facial dysmorphismand hypotrichosis (SOFT) syndrome. These main features are related to ...
Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression
(Taylor & Francis Inc, 2015)
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic ...
Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer
(Wiley-Blackwell, 2015)
Prostate cancer (PCa) is one of the leading causes of cancer deaths in men. Since there are limited treatment options available for the advanced tumors, there is an urgent need for novel diagnostic tools for PCa. Prostate ...
miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer
(Public Library Science, 2014)
Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, ...
Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: A pilot study
(Springer, 2016)
Of all human oral carcinomas, 41 % are localized to the tongue. Despite considerable improvements in both diagnosis and treatment, tongue squamous cell carcinoma (TSCC) has remained one of the most lethal types of cancer. ...
The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells
(Sage Publications Ltd., 2016)
The cancer stem-like cells (CSLCs) are tumorigenic cells promoting initiation, progression, and spread of the tumor. Accumulating evidences suggested the presence of CSLCs in distinct tumors including laryngeal squamous ...
MiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patients
(Wiley, 2015)
Larynx cancer (LCa), known to be the most commontumor of the head and neck region, accounts for about1% to 2.5% of all human neoplasms, and approximately95% to 98% of LCa is originated from squamous cell car-cinoma.1–3The ...
