Now showing items 1-10 of 15
A meta-analysis: identification of common mir-145 target Genes that have similar behavior in different GEO datasets
(Public Library Science, 2016)
Background MicroRNAs, which are small regulatory RNAs, post-transcriptionally regulate gene expression by binding 3'-UTR of their mRNA targets. Their deregulation has been shown to cause increased proliferation, migration, ...
Plasticity - Promoting Effect of Melatonin After Experimental Cerebral Ischemia
Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma
Objective: Head and neck cancer is the sixth most common cancer in worldwide with an increasing incidence rate in recent years. LOXL4 is expressed in several tissues, and its expression has been shown to display a significant ...
The role of ATP-binding cassette transporter genes in the progression of prostate cancer
Background Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of cancer-related death among men in developed countries. There is no clear evidence showing the success of current ...
Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: A pilot study
Of all human oral carcinomas, 41 % are localized to the tongue. Despite considerable improvements in both diagnosis and treatment, tongue squamous cell carcinoma (TSCC) has remained one of the most lethal types of cancer. ...
Revealing the function of a novel splice-site mutation of CHD7 in CHARGE syndrome
(Elsevier Science Bv., 2016)
Most cases of CHARGE syndrome are sporadic and autosomal dominant. CHD7 is a major causative gene of CHARGE syndrome. In this study, we screened CHD7 in two Turkish patients demonstrating symptoms of CHARGE syndrome such ...
The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells
(Sage Publications Ltd., 2016)
The cancer stem-like cells (CSLCs) are tumorigenic cells promoting initiation, progression, and spread of the tumor. Accumulating evidences suggested the presence of CSLCs in distinct tumors including laryngeal squamous ...
Role of miR-145 in human laryngeal squamous cell carcinoma
BackgroundLaryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck SCC worldwide. Incidences of laryngeal SCC have been reported to ...
The altered promoter methylation of oxytocin receptor gene in autism
(Taylor & Francis Ltd, 2016)
Autism spectrum disorder (ASD) is one of the lifelong existing disorders. Abnormal methylation status of gene promoters of oxytonergic system has been implicated as among the etiologic factors of ASDs. We, therefore, ...
Prediction of splice site using adaBoost with a new sequence encoding approach
The Biological sequence data are increasing rapidly, so there is a vital need of effective method for gene detection. Predicting of splice site is an important part of gene finding. Therefore, attempts to improve the ...