• İntramüsküler enjeksiyon uygulamasında shotblocker kullanımının etkisinin incelenmesi 

  Bedir, Hümeyra Erol (Biruni Üniversitesi, 2023)

  Bu araştırma, intramüsküler enjeksiyon uygulamalarında Shotblocker kullanımının ağrı üzerine etkisini incelemek amacıyla deneysel olarak yapıldı. Araştırma Mayıs 2022 - Ekim 2022 tarihleri arasında İstanbul'da bir eğitim ...

• 2019-nCoV virüsüne karşı etkili olabilecek moleküllerin ilaç yeniden yapılandırma ve makine öğrenim yaklaşım yöntemleri ile saptanması 

  Güner, Ersin (Biruni Üniversitesi, 2022)

  Abstract Tez kapsamında virüsün hızla yayılmasını ve kendi kendine replikasyonunu önlemek için SARS-CoV-2'nin yeni inhibitörlerinin bulunması ve inhibitör tasarlamak için derin öğrenme yöntemi kullanılarak RdRp inhibitörü ...

• The effects of morin and methotrexate on pentose phosphatepathway enzymes and GR/GST/TrxR enzyme activities:An in vivo and in silico study 

  Çağlayan, Cüneyt; Temel, Yusuf; Türkeş, Cüneyt; Ayna, Adnan; Ece, Abdulilah; Beydemir, Şükrü (Wiley, 2023)

  AbstractIn this study, the mechanisms by which the enzymes glucose‐6‐phosphatedehydrogenase (G6PD), 6‐phosphogluconate dehydrogenase (6PGD), glutathi-one reductase (GR), glutathione‐S‐transferase (GST), and thioredoxin ...

• Structural characterization of TRAF6 N-terminal for therapeutic uses and computational studies on new derivatives 

  Güven, Ömür; Sever, Belgin; Ünal, Faika Başoğlu; Ece, Abdulilah; Tateishi, Hiroshi; Koga, Ryoko; Radwan, Mohamed O.; Demir, Nefise; Can, Mustafa; Aytemir, Mutlu Dilsiz; Inoue, Jun-ichiro; Otsuka, Masami; Fujita, Mikako; Çiftçi, Halil İbrahim (MDPI, 2023)

  Abstract: Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses unique receptor binding specificity ...

• The application of nanogels as efficient drug delivery platforms for dermal/transdermal delivery 

  Siafaka, Panoraia I.; Bülbül, Ece Özcan; Okur, Mehmet Evren; Karantas, Ioannis D.; Okur, Neslihan Üstüendağ (MDPI, 2023)

  Abstract: The delivery of active molecules via the skin seems to be an efficient technology, given the various disadvantages of oral drug administration. Skin, which is the largest human organ of the body, has the important ...

• Synthesis, anti-inflammatory activity, inverse molecular docking, and acid dissociation constants of new naphthoquinone-thiazole hybrids 

  Efeoğlu, Çağla; Taşkın, Sena; Selçuk, Özge; Çelik, Begüm; Tümkaya, Ece; Ece, Abdulilah; Sarı, Hayati; Seferoğlu, Zeynel; Nural, Yahya (Elsevier, 2023)

  ABSTRACT Chronic Inflammation is associated with various types of diseases that involves pro-inflammatory cytokines like IL-6 and TNF-α. High costs and serious side effects of available anti-inflammatory/immunomodulatory ...

• Changing biotechnology dynamics - a blessing or a curse? 

  Memişoğlu, Merve (Elsevier, 2020)

  Technology and organism . . . The more artificial one is, the more natural the other. In the first place, we can think of two completely opposite concepts. However, we know that ‘the mixture of artificial intelligence ...

• Designing disposable hand-made screen-printed electrode using conductive ink for electrochemical determination of dopamine 

  Dokur, Ebrar; Uruç, Selen; Kurteli, Rabianur; Gördük, Özge; Şahin, Yücel (Springer, 2023)

  In this work, we detailed the improvement of a hand-made screen-printed electrode (SPE), which has easy production with conductive ink. The preparation of the hand-made SPE based on conductive ink to be transferred to ...

• Development of silver nanoparticles based on the method using quince seed mucilage for ascorbic acid determination 

  Begiç, Nilay (Wiley, 2023)

  Abstract Introduction: Nanoparticles are used in various fields such as chemistry, pharmacy, biotechnology, and food science since they provide higher sensitivity than traditional optical detection methods. Recently, ...

• Nose-to-brain delivery of peptides and proteins 

  Durgun, Meltem Ezgi; Çamlık, Gamze; Değim, İsmail Tuncer; Özsoy, Yıldız (Springer, 2023)

  Abstract The fact that BBB is an important obstacle in drug delivery to the brain has revealed the need o try alternative drug administration routes. One of these alternative ways, also called non-invasive administrations, ...

• Penetration of nanosized matter 

  Değim, İsmail Tuncer; Değim, Zeliha (American Scientific Publishers, 2011)

  Penetration of Nanosized Matter

• Penetration of drugs through skin 

  Değim, İsmail Tuncer; İlbasmış, S.; Dündaroz, R.; Hadgraft, J. (Jaypee Brothers Medical Publishers, 2002)

  Penetration of drugs through skin

• Pharmacophore-based virtual screening: Identification of selective sirtuin 2 inhibitors 

  Karaman Mayack, Berin; Alayoubi, Muhammed Moyasar (Marmara Üniversitesi, 2023)

  ABSTRACT: The Class III histone deacetylases protein Sirt2 has been implicated in the pathogenesis of several agerelated diseases such as inflammation, cancer, and type II diabetes and is considered an attractive novel ...

• Novel coumarin-chalcone derivatives: Synthesis, characterization, antioxidant, cyclic voltammetry, molecular modelling and biological evaluation studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors 

  Onar, Hülya Çelik; Özden, Eda Mehtap; Taslak, Hava Dudu; Gülçin, İlhami; Ece, Abdulilah; Erçağ, Erol (SpringerLink, 2023)

  ABSTRACT In this study, a total of 12 coumarin-chalcone derivatives, 6 of which are original were synthesized. The structures of the newly synthesized compounds were elucidated by 1 H NMR, 13C NMR, IR, and elemental analysis ...

• Identification of selective inhibitors for phosphodiesterase 5A using e-pharmacophore modelling and large-scale virtual screening-based structure guided drug discovery approaches 

  Maryam, Arooma; Siddiqi, Abdul Rauf; Vedithic, Sundeep Chaitanya; Ece, Abdulilah; Khalid, Rana Rehan (Taylor & Francis, 2023)

  ABSTRACT The inhibition of Phosphodiesterase 5A (PDEA5) has the potential to modulate pulmonary arterialhypertension and cardiovascular diseases. Exploring the cross-reactivity of clinically available PDE5Atherapeutics ...

• Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions 

  Güleç, Özcan; Türkeş, Cüneyt; Demir, Yeliz; Dinçer, Büşra; Ece, Abdulilah; Beydemir, Şükrü (Taylor & Francis, 2023)

  Abstract Abstract : In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was synthesized using the tail-approach method. The compounds were characterized using IR, 1H NMR, 13C NMR and ...

• Novel fluorescein isothiocyanate (FITC) cored PAMAM dendrimers as drug delivery agent 

  Bukun, Yalçın; Zaim, Merve; Şenel, Mehmet; Sağir, Tuğba; Kıyak, Berçem; Işık, Sevim (Taylor & Francis, 2023)

  Abstract Fluorescent dyes, or fluorophores, enable researchers to visualize specific biological molecules by fluorescence microscopy. Herein, a novel fluorescent FITC-poly(amidoamine) (FITC-PAMAM) dendrimers have been ...

• The role of chromatin-modifying enzymes and histone modifications in the modulation of p16 gene in fumonisin B-1-induced toxicity in human kidney cells 

  Karaman, Ecem Fatma; Abudayyak, Mahmoud; Özden, Sibel (SpringerLink, 2023)

  Abstract Fumonisin B-1 (FB1) poses a risk to animal and human health. Although the effects of FB1 on sphingolipid metabolism are well documented, there are limited studies covering the epigenetic modifications and early ...

• Heteroatom-doped graphene oxide-based conductive ink: synthesis, characterization and investigation of conductivity properties for flexible sensor technology 

  Uruç, Selen; Dokur, Ebrar; Kurteli, Rabianur; Gördük, Özge; Şahin, Yücel (Royal Society of Chemistry, 2023)

  Abstract The desire for real-time and continuous human health monitoring and uninterrupted human-machine interaction has been increasing exponentially day by day. This has opened new windows in the development of wearable ...

• The discovery of potential cyclin A/CDK2 inhibitors: a combination of 3D QSAR pharmacophore modeling, virtual screening, and molecular docking studies 

  Ece, Abdulilah; Sevin, Fatma (SpringerLink, 2013)

  Abstract Cyclin-dependent kinases are a family of enzymes that regulates the cell cycle process. They have been found to be novel targets for potential anti-cancer drugs. In the present study, a 3D pharmacophore model has ...

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