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Recent Submissions
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Transient Receptor Potential Melastatin 8 Channel Gene Expressions and Polymorphisms in Fibromyalgia Patients: A Case-Control Study
(WOLTERS KLUWER MEDKNOW Publıcatıonswolters Kluwer India Private LTD, Smartworks, Marisoft, Wing -C, Wadgaon Sheri, Kalyani Nagar Annex, Pune, Maharashtra 411014, INDIA, 2026)Introduction: This study aims to examine the relationship between transient receptor potential melastatin 8 (TRPM8) single-nucleotide polymorphisms (SNPs) (rs10166942, rs11562975), gene expression, and the development of ... -
The effect of preemptive use of nonsteroidal anti-inflammatory drug on inflammation, oxidative stress, and wound healing
(Nature Portfolıoheıdelberger Platz 3, Berlın 14197, Germany, 2026)This study evaluated the effects of preemptively administered nonsteroidal anti-inflammatory drugs (NSAIDs) on wound healing, inflammation, and oxidative stress in rats. 24 male Sprague-Dawley rats were assigned to four ... -
Design, synthesis and biological evaluation of novel benzocoumarin derivatives as potent inhibitors of MAO-B activity
(Pergamon-Elsevier Science, 2024)ABSTRACT The continued research of novel reversible inhibitors targeting monoamine oxidase (MAO) B remains crucial for effectively symptomatic treatment of Parkinson’s disease. In this study we synthesized and evaluated ... -
Gremlin-1 and Wagner Classification: Potential Biomarker for Amputation in Diabetic Foot Patients
(Sage Publication, 2025)Abstract Diabetic foot (DF) is a significant complication with high morbidity and mortality, often resulting from neuropathy and ischemia. In our study, we aimed to evaluate the relationship between serum Gremlin-1 levels ... -
Impact of High-Intensity Interval Training on Bone Metabolism and the Metabolic and Hormonal Profiles of Postmenopausal Women
(Galenos Publ House, 2025)Abstract Introduction: Although many forms of exercise are known to have positive effects on bone metabolism in postmenopausal women, the effect of high-intensity interval training (HIIT) has not been investigated in this ... -
Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex
(Nature Portfolio, 2025)Abstract Our study aims to determine the effects of alamandine, the newest component of the renin-angiotensin system, on cognitive functions, neuroinflammation, and oxidative stress in the pathophysiology of depression. ... -
The Effect of Thymoquinone and Platelet-Rich Plasma on Intra-Abdominal Adhesions
(MDPI, 2025)Abstract Background and Objectives: At present, intra-abdominal adhesions (IAAs) continue to be an important problem in surgery due to morbidity and mortality risks. Thymoquinone (TQ) and platelet-rich plasma (PRP) are ... -
The relationship between the level of soluble CD40 ligand and angiographic extent and severity of coronary artery disease
(Czech Soc Cardiology & Czech Soc Cardiovascular Surgery, 2023)ABSTRACT Objectives: Previous studies have suggested that atherosclerosis is a chronic infl ammatory disease and implicate components of the immune system in atherogenesis. The CD40 and CD40 ligand system regulates multiple ... -
The Importance of Resolvin D1, LXA4, and LTB4 in Patients with Acute Pancreatitis Due to Gallstones
(MDPI, 2025)Abstract: Background and Objectives: Acute pancreatitis (AP) is an inflammatory disease where there is autodigestion of the pancreas by prematurely activated enzymes which may lead to a systemic inflammatory response. ... -
Evaluation of Thrombomodulin, Heart-Type Fatty-Acid-Binding Protein, Pentraxin-3 and Galectin-3 Levels in Patients with Myocardial Infarction, with and Without ST Segment Elevation
(MDPI, 2025)Abstract: Background: Medical history, ECG findings and cardiac markers are used in the diagnosis of myocardial infarction (MI). Biomarkers used especially for the diagnosis of MI include high-sensitivity troponins ... -
Chemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques
(Elsevier, 2025)ABSTRACT This study employed Fourier transform infrared (FTIR) spectroscopy to determine the chemical composition of brain tissues and the changes induced by irisin at doses of 50 mg and 100 mg. Brain tissues were collected ... -
Chemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques
(Academic Press Inc Elsevier Science, 2025)Abstract This study employed Fourier transform infrared (FTIR) spectroscopy to determine the chemical composition of brain tissues and the changes induced by irisin at doses of 50 mg and 100 mg. Brain tissues were collected ... -
Chemical composition alterations in rat brain hypothalamus induced by irisin administration using spectroscopic and machine learning techniques
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2025)Abstract This study employed Fourier transform infrared (FTIR) spectroscopy to determine the chemical composition of brain tissues and the changes induced by irisin at doses of 50 mg and 100 mg. Brain tissues were collected ... -
Arylcoumarin and novel biscoumarin derivatives as potent inhibitors of human glutathione S-transferase
(Taylor & Francis Inc, 2023)ABSTRACT A series of arylcoumarin derivatives and two novel biscoumarin derivatives were investigated for their human recombinant glutathione S-transferase P1-1 (GSTP1-1) enzyme inhibitory activities for the first time. ... -
Kolorektal kanserde lncRNA DPP10-AS1 ekspresyonu tümör baskılayıcı ve tümör mikroçevresinde metabolit transportuyla ilişkili olabilir mi?
(Türk Gastroenteroloji Vakfı, 2022)Giriş ve Amaç: Onkogen ve tümör baskılayıcı gen ifadeleri başta olmak üzere birçok ribonükleik asit ve proteinle moleküler etkileşimde bulunabilen uzun kodlanmayan ribonükleik asitler solid organ kanserlerinde ilişkilendirilmeye ... -
Investigation of long non-coding RNAs H19 and LINC00675 in colorectal cancers in terms of histopathological features and correlations with plasma markers
(International Institute of Anticancer Research, 2022)Background/aim: Functional and bioinformatic studies provide strong evidence that long non-coding RNAs (lncRNAs) can alter the molecular mechanisms of cancer through their interactions with DNA, RNAs, and proteins. This ... -
Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells
(Taylor & Francis, 2021)Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell ... -
Effects of genetic variations of MLCK2, AMPD1, and COL5A1 on muscle endurance
(Redprint Editora, 2022)Introduction: Although potential relationships with genetic variants of MLCK2, AMPD1 and COL5A1 have been detected in molecular studies evaluating sports performance from the genetic perspective, there are limited data in ... -
Evaluation of oxidative stress and inflammatory biomarkers pre and post-treatment in new diagnosed atherosclerotic patients
(Taylor and Francis, 02.2022)Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. It is characterized by lipid accumulation in the arterial wall, increased hyperlipidemia, oxidative ... -
The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer
(De Gruyter, 2021)Abstract: Objectives: Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many cancer types. However, there are limited studies of these ...
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