Yayın tarihi için Biyomedikal Mühendisliği listeleme
Toplam kayıt 25, listelenen: 1-20
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In vitro investigations of miR 33a expression in estrogen receptor targeting therapies in breast cancer cells
(MDPI, 01.11.2021)Background: Increased fatty acid synthesis leads to the aggressive phenotype of breast cancer and renders efficiency of therapeutics. Regulatory microRNAs (miRNAs) on lipid biosynthesis pathways as miR-33a have potential ... -
Synthesis and characterization of novel ssDNA X-aptamers targeting growth hormone releasing hormone (GHRH)
(Public Library of Science, 01.2022)Background Growth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids. GHRH (NH2 1-29) peptide antagonists inhibit the growth of ... -
Adult mouse dorsal root ganglia neurons form aberrant glutamatergic connections in dissociated cultures
(Public Library of Science, 03.2021)Cultured sensory neurons can exhibit complex activity patterns following stimulation in terms of increased excitability and interconnected responses of multiple neurons. Although these complex activity patterns suggest a ... -
Stochastic optimal control analysis for the hepatitis B epidemic model
(Elsevier, 07.2021)Mathematical formulation of a stochastic hepatitis B virus (HBV) model with the application of optimal control and randomly noise transmission has been focused in this paper. For the ease of understanding, the model is ... -
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F
(MDPI, 07.2022)The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell ... -
Elucidating the roles of naturally occurring silent mutations in Polycystic Ovary Syndrome (PCOS)
(Elsevier, 09.2020)Polycystic ovary syndrome (PCOS) is a complex genetic disorder, which often causes infertility in women. Most of the PCOS-related genes are also linked with metabolic diseases, inflammatory responses, or certain types of ... -
Epibrassinolide prevents tau hyperphosphorylation via GSK3β inhibition in vitro and improves caenorhabditis elegans lifespan and motor deficits in combination with roscovitine
(Springer, 09.2021)Glycogen synthase kinase 3β (GSK3β) is considered an important element of glycogen metabolism; however, it has many other regulatory roles. Changes in the GSK3β signaling mechanism have been associated with various disorders, ... -
Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease
(Elsevier, 12.2021)Personalized medicine is one of the popular approaches in biological sciences. Due to the great attention in personalized medicine, there exists a need for health decision algorithms developed through high-level programming ... -
Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1
(Elsevier, 15.01.2023)Human microsomal prostaglandin E synthase (mPGES)-1 is a glutathione-dependent membrane-bound enzyme which is involved in the terminal stage of prostaglandin E2 (PGE2) synthesis. It has been well reported as a key target ... -
Code design for discrete memoryless interference channels
(Ieee-Inst Electrical Electronics Engineers Inc, 2018)We study the design of explicit and implementable codes for the two-user discrete memoryless interference channels (DMICs). We consider Han-Kobayashi (HK) type encoding where both public and private messages are used and ... -
Short block length trellis-based codes for interference channels
(Inst Engineering Technology-IET, 2018)In this study, the authors consider Gaussian interference channels and fading interference channels, and design short block length codes based on trellis-based constructions. For both joint maximum likelihood (JML) decoding ... -
Bioinks for 3D bioprinting: An overview
(Royal Soc Chemistry, 2018)Bioprinting is an emerging technology with various applications in making functional tissue constructs to replace injured or diseased tissues. It is a relatively new approach that provides high reproducibility and precise ... -
Denoising AMP for MRI reconstruction: BM3D-AMP-MRI
(Society for Industrial and Applied Mathematics, 2018)There is a recurrent idea being promoted in the recent literature on iterative solvers for imaging problems, the idea being the use of an actual denoising step in each iteration. We give a brief review of some algorithms ... -
LDPC codes for interference channels in the primary decodes cognitive regime
(IEEE, 2019)We investigate cognitive interference channels (CICs), a variant of two-user ICs in which one of the transmitters (called the cognitive transmitter) has non-causal knowledge of the other's (private user's) message. Prompted ... -
LDPC code design for fading interference channels
(IEEE-INST Electrical Electronics Engineers Inc, 2019)We focus on the two-user Gaussian interference channel (IC) with fading and study implementation of different encoding/ decoding schemes with low-density parity-check (LDPC) codes for both quasi-static and fast fading ... -
Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells
(Springer Nature, 2021)Abstract Purpose: The constitutive activation of STAT3 through receptor tyrosine kinases triggered breast cancer cell growth and invasion-metastasis. Atiprimod impacts anti-proliferative, anti-carcinogenic effects in ... -
Optical solitons to the Fokas system equation in monomode optical fbers
(Springer Nature, 2022)Abstract In this work, we investigate the Fokas system which expresses the nonlinear pulse propagation in mono-mode optical fbers. We use the ( m + 1 G� ) -expansion scheme and the novel modifed generalized exponential ... -
The comparison of differentially expressed microRNAs in Bag-1 deficient and wild type MCF-7 breast cancer cells by small RNA sequencing
(TUBITAK, 2022)The multifunctional BAG-1 (Bcl-2 athanogene-1) protein promotes breast cancer survival through direct or indirect interaction partners. The number of the interacting partners determines its cellular role in different ... -
Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity
(Springer Nature, 2022)Abstract Abstract: Some novel triazole-bearing ketone and oxime derivatives were synthesized from Ibuprofen. In vitro cytotoxic activities of all synthesized molecules against five cancer lines (human breast cancer MCF-7, ...
