Browsing Biyomedikal Mühendisliği by Subject "Angiogenesis"

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Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity

Bülbül, Bahadır; Ding, Kai; Zhan, Chang-Guo; Çiftçi, Gamze; Yelekçi, Kemal; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Aydemir, Esra; Baybağ, Deniz; Şahin, Fikrettin; Kulabaş, Necla; Helvacıoğlu, Sinem; Charehsaz, Mohammad; Tatar, Esra; Özbey, Süheyla; Küçükgüzel, İlkay (Springer Nature, 2022)

Abstract Abstract: Some novel triazole-bearing ketone and oxime derivatives were synthesized from Ibuprofen. In vitro cytotoxic activities of all synthesized molecules against five cancer lines (human breast cancer MCF-7, ...
Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1

Erensoy, Gizem; Ding, Kai; Zhan, Chang-Guo; Çiftçi, Gamze; Yelekçi, Kemal; Duracık, Merve; Bingöl Özakpınar, Özlem; Aydemir, Esra; Yılmaz, Zübeyde Nur; Şahin, Fikrettin; Kulabaş, Necla; Tatar, Esra; Küçükgüzel, İlkay (Elsevier, 15.01.2023)

Human microsomal prostaglandin E synthase (mPGES)-1 is a glutathione-dependent membrane-bound enzyme which is involved in the terminal stage of prostaglandin E2 (PGE2) synthesis. It has been well reported as a key target ...