Makale Koleksiyonu
Recent Submissions
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Relationship between expression levels of TDRD7 and CRYBB3 and development of age-related cortico-nuclear cataracts
(Springer Nature, 2023)Background: The human lens develops age-related cataracts (ARCs) because of the complicated effects of aging and stressful conditions. Under conditions involving oxidative stress, cells form stress granules (SGs). TDRD7 ... -
A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease
(Elsevier, 2022)Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this ... -
Investigation of the expression levels of CDH1, FHIT, PTEN, and TTPAL genes in colorectal tumors
(Scientific and Technical research Council of Turkey, 2022)Background/aim: The main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV. Materials and methods: Gene ... -
Importance of diagnosis in breast cancer with non-BRCA pathogenic germline variants of cancer susceptibility genes using high-throughput sequencing analysis
(Kare Publishing, 2022)Abstract Objectives: The aim was to point out the importance of the diagnosis rate of breast cancer (BC) by analyzing the cancer predisposition genes except BRCA1/2 with multigene testing. Methods: In this study, 232 ... -
The diagnostic and predictive roles of neutrophil lymphocyte ratio for severity of disease in COVID 19 patients
(Clinical Laboratory, 2021)Neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR) are inflammation markers in inflammatory, cardiovascular, and malignant diseases and are important to assess prognosis. ... -
COVID 19 seroconversion in the aircrew from Turkey
(Elsevier, 2021)Background: Pneumonia due to Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) is spreading rapidly all over the world and air travel is the leading transmission route of the virus among countries. The aim of the study is ... -
High EZH2 expression in ductal carcinoma in situ diagnosed on breast core needle biopsy is an independent predictive factor for upgrade on surgical excision
(Elsevier GmbH, 03.11.2020)Purpose: Approximately 25 % of DCIS diagnosed on breast core needle biopsy (CNB) is upgraded to invasive carcinoma on surgical excision. Risk factors to predict the upgrade on excision are not well established, leading ... -
Regenerative endodontic procedures in necrotic mature teeth with periapical radiolucencies: A preliminary randomized clinical study
(Elsevier B.V., 2019)Abstract Introduction: This preliminary study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) with that of conventional root canal treatment (CRCT) in necrotic mature teeth with ... -
Histologic evaluation of regenerated tissues in the pulp spaces of teeth with mature roots at the time of the regenerative endodontic procedures
(Elsevier B.V., 2019)Introductıon: Recently, regenerative endodontic procedures (REPs) have been used to treat mature permanent teeth with apical periodontitis. Although animal studies with regard to histopathological findings after REPs exist, ... -
Novel MASP1 mutations are associated with an expanded phenotype in 3MC1 syndrome
(BioMed Central Ltd, 2015)Background: 3MC1 syndrome is a rare autosomal recessive disorder characterized by intellectual disability, short stature and distinct craniofacial, umbilical, and sacral anomalies. Five mutations in MASP1, encoding lectin ... -
Alpha-B-crystallin expression in human laryngeal squamous cell carcinoma tissues
(Wiley, 2015)BackgroundLaryngeal squamous cell carcinoma (SCC), being an aggressive malignancy, is one of the most commonly diagnosed malignant types of head and neck SCC worldwide. The recent studies suggested that B-crystallin might ... -
Differential expression of stem cell markers and ABCG2 in recurrent prostate cancer
(Wiley-Blackwell, 2014)Background. Prostate cancer (PCa) is the second most common tumor type related to mortality in males in the developed countries. Studies have demonstrated that therapeutic tools mostly ineffective to give positive outcome ... -
miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer
(Public Library Science, 2014)Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, ... -
Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: A pilot study
(Springer, 2016)Of all human oral carcinomas, 41 % are localized to the tongue. Despite considerable improvements in both diagnosis and treatment, tongue squamous cell carcinoma (TSCC) has remained one of the most lethal types of cancer. ... -
Revealing the function of a novel splice-site mutation of CHD7 in CHARGE syndrome
(Elsevier Science Bv., 2016)Most cases of CHARGE syndrome are sporadic and autosomal dominant. CHD7 is a major causative gene of CHARGE syndrome. In this study, we screened CHD7 in two Turkish patients demonstrating symptoms of CHARGE syndrome such ... -
Investigation of hepatitis a and e viruses in mussels collected from the bosphorus, in Istanbul, Turkey - short communication
(Czech Academy of Agricultural Sciences, 2018)Hepatitis A and E viruses (HAV and HEV) are recognised as food- and water-borne infections and shellfish are a well-documented source of these viruses. The presence of HAV and HEV in mussels has not previously been ...
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